『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=98190EID:98190, Map:0, LastModified:2014年2月14日(金) 12:46:21, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[細井 和雄], Read:継承, Write:継承, Delete:継承.
種別 (必須): 国際会議 [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Yano Yoko (日) (読)
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学籍番号 (推奨):
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2. (英) Ozono Ryoji (日) (読)
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[継承]
3. (英) Nakashima Hidekatu (日) (読)
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4. (英) Oishi Yoshihiko (日) (読)
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[継承]
5. (英) Kambe Masayuki (日) (読)
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6.細井 和雄
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7. (英) Oshima Tetsuya (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Immunohistochemical distributions of the tissue kallikrein-kinin system in ischemic and non-ischemic mouse heart  (日)    [継承]
副題 (任意):
要約 (任意): (英) Kinins have been shown to play a cardioprotective role during myocardial ischemia. However, the localization of each of the components of the kallikrein-kinin system in the heart has not been determined in a cell type-specific manner. Recently, mK1 has been identified as the major tissue kallikrein with the strongest bradykinin-forming activity among the products of the mouse tissue kallikrein gene superfamily. In the study presented here, we investigated the localizations of mK1, kininogen and bradykinin B2 receptors (B2Rs) in ischemic and non-ischemic left ventricles by immunohistochemistry. Kininogen, which contains bradykinin as a surface epitope, was detected by an anti-bradykinin antibody. Changes in the amounts of mK1 and B2R were evaluated by Western blot analysis. Myocardial ischemia was induced by ligation of the left anterior descending coronary artery for 60 min followed by reperfusion for 24 h. mK1 and B2Rs were most abundantly expressed in the vascular endothelium and, to a lesser extent, in fibroblasts. No immunohistochemical signal of these molecules was detected in myocytes. Kininogen was localized in the vascular endothelium and the smooth muscle layer. Myocardial ischemia, although it had no effect on the localization of these molecules, increased the amounts of mK1 and B2R. We have obtained immunohistochemical evidence that all components of the tissue kallikrein-kinin system are present in the mouse heart. The coronary artery is the major site of kallikrein-kinin activity both in ischemic and non-ischemic hearts.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Blotting, Western (日) (読) [継承]
3. (英) Bradykinin (日) (読) [継承]
4. (英) Coronary Vessels (日) (読) [継承]
5. (英) Endothelium, Vascular (日) (読) [継承]
6. (英) Epitopes (日) (読) [継承]
7. (英) Heart Ventricles (日) (読) [継承]
8. (英) Immunoenzyme Techniques (日) (読) [継承]
9. (英) Kallikrein-Kinin System (日) (読) [継承]
10. (英) Kininogen, High-Molecular-Weight (日) (読) [継承]
11. (英) Kininogen, Low-Molecular-Weight (日) (読) [継承]
12. (英) Ligation (日) (読) [継承]
13. (英) Male (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Mice, Inbred C57BL (日) (読) [継承]
16. (英) Myocardial Ischemia (日) (読) [継承]
17. (英) Receptor, Bradykinin B2 (日) (読) [継承]
18. (英) Reperfusion (日) (読) [継承]
19. (英) Time Factors (日) (読) [継承]
20. (英) Tissue Kallikreins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Cardiovascular Pharmacology ([Lippincott Williams & Wilkins])
(pISSN: 0160-2446, eISSN: 1533-4023)

ISSN (任意): 0160-2446
ISSN: 0160-2446 (pISSN: 0160-2446, eISSN: 1533-4023)
Title: Journal of cardiovascular pharmacology
Title(ISO): J Cardiovasc Pharmacol
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 42 [継承]
(必須): Suppl.1 [継承]
(必須): S49 S53 [継承]
都市 (必須):
年月日 (必須): 西暦 2003年 12月 初日 (平成 15年 12月 初日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 14871029    (→Scopusで検索) [継承]
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WOS (任意): 000187044500012 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Clinical Laboratory Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yoko Yano, Ryoji Ozono, Hidekatu Nakashima, Yoshihiko Oishi, Masayuki Kambe, Kazuo Hosoi and Tetsuya Oshima : Immunohistochemical distributions of the tissue kallikrein-kinin system in ischemic and non-ischemic mouse heart, Journal of Cardiovascular Pharmacology, Vol.42, No.Suppl.1, S49-S53, (都市), Dec. 2003.
欧文冊子 ● Yoko Yano, Ryoji Ozono, Hidekatu Nakashima, Yoshihiko Oishi, Masayuki Kambe, Kazuo Hosoi and Tetsuya Oshima : Immunohistochemical distributions of the tissue kallikrein-kinin system in ischemic and non-ischemic mouse heart, Journal of Cardiovascular Pharmacology, Vol.42, No.Suppl.1, S49-S53, (都市), Dec. 2003.

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