| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | Medical College of Wisconsin
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| ○著者 (必須): | 1. | 田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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| 2. | (英) Ludwig LM (日) (読)
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| 3. | (英) Krolilowski, JG (日) (読)
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| 4. | (英) Alcindor D (日) (読)
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| 5. | (英) Pratt PF (日) (読)
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| 6. | (英) Kersten JR (日) (読)
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| 7. | (英) Pagel PS (日) (読)
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| 8. | (英) Warltier DC (日) (読)
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| ○題名 (必須): | □ | (英) Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2. (日)
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| ○要約 (任意): | □ | (英) Whether volatile anesthetics produce a second window of preconditioning is unclear. The authors tested the hypothesis that isoflurane causes delayed preconditioning against infarction and, further, that cyclooxygenase (COX)-2 mediates this beneficial effect. Rabbits (n = 43) were randomly assigned to receive 0.9% intravenous saline, the selective COX-2 inhibitor celecoxib (3 mg/kg intraperitoneal) five times over 2 days before coronary artery occlusion and reperfusion, or isoflurane (1.0 minimum alveolar concentration) 24 h before acute experimentation in the absence or presence of celecoxib pretreatment. Two additional groups of rabbits received a single dose of celecoxib either 30 min before or 21.5 h after administration of isoflurane. Rabbits were then instrumented for measurement of hemodynamics and underwent 30 min of coronary occlusion followed by 3 h of reperfusion. Myocardial infarct size was measured using triphenyltetrazolium staining. Western immunoblotting to examine COX-1 and COX-2 protein expression was performed in rabbit hearts that had or had not been exposed to isoflurane. Isoflurane significantly (P < 0.05) reduced infarct size (22 +/- 3% of the left ventricular area at risk) as compared with control (39 +/- 2%). Celecoxib alone had no effect on infarct size (36 +/- 4%) but abolished isoflurane-induced cardioprotection (36 +/- 4%). A single dose of celecoxib administered 2.5 h before coronary occlusion and reperfusion also abolished the delayed protective effects of isoflurane (36 +/- 4%), but celecoxib given 30 min before exposure to isoflurane had no effect (22 +/- 4%). Isoflurane did not alter COX-1 and COX-2 protein expression. The results indicate that the volatile anesthetic isoflurane produces a second window of preconditioning against myocardial ischemia and reperfusion injury. Furthermore, COX-2 is an important mediator of isoflurane-induced delayed preconditioning. (日)
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| ○キーワード (推奨): | 1. | (英) Anesthetics, Inhalation (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Blood Pressure (日) (読)
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| 4. | (英) Blotting, Western (日) (読)
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| 5. | (英) Coronary Circulation (日) (読)
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| 6. | (英) Cyclooxygenase 1 (日) (読)
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| 7. | (英) Cyclooxygenase 2 (日) (読)
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| 8. | (英) Cyclooxygenase 2 Inhibitors (日) (読)
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| 9. | (英) Cyclooxygenase Inhibitors (日) (読)
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| 10. | (英) Heart Rate (日) (読)
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| 11. | (英) Ischemic Preconditioning, Myocardial (日) (読)
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| 12. | (英) Isoenzymes (日) (読)
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| 13. | (英) Isoflurane (日) (読)
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| 14. | (英) Male (日) (読)
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| 15. | (英) Myocardial Infarction (日) (読)
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| 16. | (英) Myocardial Ischemia (日) (読)
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| 17. | (英) Myocardial Reperfusion Injury (日) (読)
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| 18. | (英) Prostaglandin-Endoperoxide Synthases (日) (読)
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| 19. | (英) Pyrazoles (日) (読)
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| 20. | (英) Rabbits (日) (読)
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| 21. | (英) Sulfonamides (日) (読)
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| 22. | (英) Ventricular Function, Left (日) (読)
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| ○発行所 (推奨): | □ | The American Society of Anesthesiologists
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| ○誌名 (必須): | □ | Anesthesiology ([The American Society of Anesthesiologists])
(pISSN: 0003-3022, eISSN: 1528-1175)
| ○ISSN (任意): | □ | 0003-3022
ISSN: 0003-3022
(pISSN: 0003-3022, eISSN: 1528-1175) Title: AnesthesiologyTitle(ISO): AnesthesiologyPublisher: Lippincott Williams & Wilkins Ltd. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 100
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 525 531
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2004年 3月 初日 (平成 16年 3月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1097/00000542-200403000-00010 (→Scopusで検索)
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| ○PMID (任意): | □ | 15108964 (→Scopusで検索)
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| ○NAID (任意): |
| ○WOS (任意): | □ | 000189251700009
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| ○評価値 (任意): |
| ○被引用数 (任意): | □ | 13
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: In Vitro (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S. (日)
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