『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=94651EID:94651, Map:0, LastModified:2013年6月21日(金) 16:30:00, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[田中 克哉], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.Medical College of Wisconsin [継承]
著者 (必須): 1.田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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[継承]
2. (英) Ludwig LM (日) (読)
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[継承]
3. (英) Krolilowski, JG (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Alcindor D (日) (読)
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[継承]
5. (英) Pratt PF (日) (読)
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[継承]
6. (英) Kersten JR (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Pagel PS (日) (読)
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[継承]
8. (英) Warltier DC (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Whether volatile anesthetics produce a second window of preconditioning is unclear. The authors tested the hypothesis that isoflurane causes delayed preconditioning against infarction and, further, that cyclooxygenase (COX)-2 mediates this beneficial effect. Rabbits (n = 43) were randomly assigned to receive 0.9% intravenous saline, the selective COX-2 inhibitor celecoxib (3 mg/kg intraperitoneal) five times over 2 days before coronary artery occlusion and reperfusion, or isoflurane (1.0 minimum alveolar concentration) 24 h before acute experimentation in the absence or presence of celecoxib pretreatment. Two additional groups of rabbits received a single dose of celecoxib either 30 min before or 21.5 h after administration of isoflurane. Rabbits were then instrumented for measurement of hemodynamics and underwent 30 min of coronary occlusion followed by 3 h of reperfusion. Myocardial infarct size was measured using triphenyltetrazolium staining. Western immunoblotting to examine COX-1 and COX-2 protein expression was performed in rabbit hearts that had or had not been exposed to isoflurane. Isoflurane significantly (P < 0.05) reduced infarct size (22 +/- 3% of the left ventricular area at risk) as compared with control (39 +/- 2%). Celecoxib alone had no effect on infarct size (36 +/- 4%) but abolished isoflurane-induced cardioprotection (36 +/- 4%). A single dose of celecoxib administered 2.5 h before coronary occlusion and reperfusion also abolished the delayed protective effects of isoflurane (36 +/- 4%), but celecoxib given 30 min before exposure to isoflurane had no effect (22 +/- 4%). Isoflurane did not alter COX-1 and COX-2 protein expression. The results indicate that the volatile anesthetic isoflurane produces a second window of preconditioning against myocardial ischemia and reperfusion injury. Furthermore, COX-2 is an important mediator of isoflurane-induced delayed preconditioning.  (日)    [継承]
キーワード (推奨): 1. (英) Anesthetics, Inhalation (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Blood Pressure (日) (読) [継承]
4. (英) Blotting, Western (日) (読) [継承]
5. (英) Coronary Circulation (日) (読) [継承]
6. (英) Cyclooxygenase 1 (日) (読) [継承]
7. (英) Cyclooxygenase 2 (日) (読) [継承]
8. (英) Cyclooxygenase 2 Inhibitors (日) (読) [継承]
9. (英) Cyclooxygenase Inhibitors (日) (読) [継承]
10. (英) Heart Rate (日) (読) [継承]
11. (英) Ischemic Preconditioning, Myocardial (日) (読) [継承]
12. (英) Isoenzymes (日) (読) [継承]
13. (英) Isoflurane (日) (読) [継承]
14. (英) Male (日) (読) [継承]
15. (英) Myocardial Infarction (日) (読) [継承]
16. (英) Myocardial Ischemia (日) (読) [継承]
17. (英) Myocardial Reperfusion Injury (日) (読) [継承]
18. (英) Prostaglandin-Endoperoxide Synthases (日) (読) [継承]
19. (英) Pyrazoles (日) (読) [継承]
20. (英) Rabbits (日) (読) [継承]
21. (英) Sulfonamides (日) (読) [継承]
22. (英) Ventricular Function, Left (日) (読) [継承]
発行所 (推奨): The American Society of Anesthesiologists [継承]
誌名 (必須): Anesthesiology ([The American Society of Anesthesiologists])
(pISSN: 0003-3022, eISSN: 1528-1175)

ISSN (任意): 0003-3022
ISSN: 0003-3022 (pISSN: 0003-3022, eISSN: 1528-1175)
Title: Anesthesiology
Title(ISO): Anesthesiology
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 100 [継承]
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(必須): 525 531 [継承]
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年月日 (必須): 西暦 2004年 3月 初日 (平成 16年 3月 初日) [継承]
URL (任意):
DOI (任意): 10.1097/00000542-200403000-00010    (→Scopusで検索) [継承]
PMID (任意): 15108964    (→Scopusで検索) [継承]
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WOS (任意): 000189251700009 [継承]
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評価値 (任意):
被引用数 (任意): 13 [継承]
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: In Vitro  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● Katsuya Tanaka, LM Ludwig, JG Krolilowski, D Alcindor, PF Pratt, JR Kersten, PS Pagel and DC Warltier : Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2., Anesthesiology, Vol.100, No.3, 525-531, 2004.
欧文冊子 ● Katsuya Tanaka, LM Ludwig, JG Krolilowski, D Alcindor, PF Pratt, JR Kersten, PS Pagel and DC Warltier : Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2., Anesthesiology, Vol.100, No.3, 525-531, 2004.

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