『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=93925)

EID=93925EID:93925, Map:0, LastModified:2014年12月11日(木) 15:59:02, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[谷 憲治], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.先端医療創生科学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.谷 憲治 ([徳島大学.病院.中央診療施設等.総合診療部]/[徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).総合診療医学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Ogushi Fumitaka (日) 大串 文隆 (読) おおぐし ふみたか
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Huang Luping (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Sone Saburo (日) 曽根 三郎 (読) そね さぶろう
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) CD13/aminopeptidase N: A novel chemoattractant for T lymphocytes in pulmonary sarcoidosis  (日)    [継承]
副題 (任意):
要約 (任意): (英) CD13/aminopeptidase N (E.C.3.4.11.2) is an ectoenzyme located in the outer membrane of a variety of cells. Because aminopeptidase expression was shown to be upregulated by a Th1-related cytokine, IFN-gamma, we examined here the significance of CD13/aminopeptidase N in pulmonary sarcoidosis. The activity of aminopeptidase in bronchoalveolar lavage fluid (BALF) was significantly higher in patients with sarcoidosis than in normal volunteers (NV) and control patients (CP). The activity significantly correlated with lymphocyte percentages and the ratio of CD4+ to CD8+ T lymphocytes in the BALF, and was higher in patients with sarcoidosis with parenchymal involvement than in those without the involvement. CD13/aminopeptidase N protein, which has a molecular mass of approximately 150 kD, was detectable in alveolar macrophages (AM) from patients with sarcoidosis at higher levels than in those from NV. CD13/aminopeptidase N induced in vitro chemotactic migration of human lymphocytes in a concentration range of 10(-)(5) to 10(-)(1) U/ml. The chemotactic activity was greater for CD4+ T lymphocytes than for CD8+ T lymphocytes. The enzymatic activity of CD13/aminopeptidase N was responsible for the chemotactic activity because bestatin, an inhibitor of CD13/aminopeptidase N, abolished the chemotactic activity. Higher chemotactic activity for lymphocytes was detected in the BALF from patients with sarcoidosis than in that from NV, and the activity was significantly decreased by treatment with bestatin. This study indicates that CD13/ aminopeptidase N expressed in AM may have a role in T-lymphocyte involvement in the sarcoid lung and the pathogenesis of alveolitis in this disorder.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Aminopeptidases (日) (読) [継承]
3. (英) Antigens, CD13 (日) (読) [継承]
4. (英) Blotting, Western (日) (読) [継承]
5. (英) Bronchoalveolar Lavage Fluid (日) (読) [継承]
6. (英) Chemotaxis, Leukocyte (日) (読) [継承]
7. (英) Enzyme Inhibitors (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Interferon-gamma (日) (読) [継承]
11. (英) Interleukin-2 (日) (読) [継承]
12. (英) Leucine (日) (読) [継承]
13. (英) Macrophages, Alveolar (日) (読) [継承]
14. (英) Male (日) (読) [継承]
15. (英) Middle Aged (日) (読) [継承]
16. (英) Peptidyl-Dipeptidase A (日) (読) [継承]
17. (英) Sarcoidosis, Pulmonary (日) (読) [継承]
18.Tリンパ球 (T lymphocytes) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Respiratory and Critical Care Medicine (American Thoracic Society/American Lung Association)
(pISSN: 1073-449X, eISSN: 1535-4970)

ISSN (任意): 1073-449X
ISSN: 1073-449X (pISSN: 1073-449X, eISSN: 1535-4970)
Title: American journal of respiratory and critical care medicine
Title(ISO): Am. J. Respir. Crit. Care Med.
Publisher: American Thoracic Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 161 [継承]
(必須): 5 [継承]
(必須): 1636 1642 [継承]
都市 (任意):
年月日 (必須): 西暦 2000年 5月 初日 (平成 12年 5月 初日) [継承]
URL (任意):
DOI (任意): 10.1164/ajrccm.161.5.9902008    (→Scopusで検索) [継承]
PMID (任意): 10806168    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000086945400042 [継承]
Scopus (任意): 2-s2.0-0034126283 [継承]
機関リポジトリ (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Third Department of Internal Medicine, School of Medicine, Tokushima University, Tokushima, Japan. kenjikt@clin.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kenji Tani, Fumitaka Ogushi, Luping Huang and Saburo Sone : CD13/aminopeptidase N: A novel chemoattractant for T lymphocytes in pulmonary sarcoidosis, American Journal of Respiratory and Critical Care Medicine, Vol.161, No.5, 1636-1642, 2000.
欧文冊子 ● Kenji Tani, Fumitaka Ogushi, Luping Huang and Saburo Sone : CD13/aminopeptidase N: A novel chemoattractant for T lymphocytes in pulmonary sarcoidosis, American Journal of Respiratory and Critical Care Medicine, Vol.161, No.5, 1636-1642, 2000.

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