『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=72347EID:72347, Map:0, LastModified:2016年9月9日(金) 14:34:12, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.歯学部.歯学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Hino Satoshi (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Kawamaha Hitoshi (日) (読)
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3.表原 文江
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4.内田 大亮
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5. (英) Miwa Yoshihiro (日) (読)
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6. (英) Begum NM (日) (読)
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7.吉田 秀夫
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8.佐藤 光信
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9. (英) Fujimori Takahiro (日) (読)
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題名 (必須): (英) Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) We transfected a salivary gland cancer cell line, TYS, with three different forms of TSC-22 (transforming growth factor-beta-stimulated clone-22) gene: full-length TSC-22 (TSC-22FL) containing nuclear export signal, TSC-box and leucine zipper, truncated TSC-22 (TSC-22LZ) containing only TSC-box and leucine zipper, and truncated TSC-22 with nuclear localization signal (NLS-TSC-22LZ). High expression of TSC-22FL in the cytoplasm markedly enhanced the radiation-sensitivity of TYS cells, while, moderate expression of TSC-22FL marginally affected the radiation-sensitivity. TSC-22LZ, which was expressed in the cytoplasm and the nucleus, enhanced the radiation-sensitivity of TYS cells irrespective to its expression level. NLS-TSC-22LZ, which was expressed only in the nucleus, marginally affected the radiation-sensitivity of the cells even at high expression level. Interestingly, cytoplasmic TSC-22 translocates to nucleus concomitant with radiation-induced apoptosis. These results suggest that cytoplasmic localization of TSC-22 and translocation of TSC-22 from cytoplasm to nucleus is important for regulating the cell death signal after irradiation-induced DNA damage.  (日)    [継承]
キーワード (推奨): 1. (英) Active Transport, Cell Nucleus (日) (読) [継承]
2. (英) Amino Acid Motifs (日) (読) [継承]
3.アポトーシス (apoptosis) [継承]
4.細胞周期 (cell cycle) [継承]
5.細胞分裂 (cell division) [継承]
6. (英) Cell Nucleus (日) (読) [継承]
7. (英) Cytoplasm (日) (読) [継承]
8. (英) Green Fluorescent Proteins (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Leucine Zippers (日) (読) [継承]
11. (英) Luminescent Proteins (日) (読) [継承]
12. (英) Nuclear Localization Signals (日) (読) [継承]
13. (英) Radiation Tolerance (日) (読) [継承]
14. (英) Recombinant Fusion Proteins (日) (読) [継承]
15. (英) Repressor Proteins (日) (読) [継承]
16. (英) Salivary Gland Neoplasms (日) (読) [継承]
17. (英) Sequence Deletion (日) (読) [継承]
18. (英) Transfection (日) (読) [継承]
19. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)

ISSN (任意): 0006-291X
ISSN: 0006-291X (pISSN: 0006-291X, eISSN: 1090-2104)
Title: Biochemical and biophysical research communications
Title(ISO): Biochem. Biophys. Res. Commun.
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 957 963 [継承]
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年月日 (必須): 西暦 2002年 4月 12日 (平成 14年 4月 12日) [継承]
URL (任意):
DOI (任意): 10.1006/bbrc.2002.6776    (→Scopusで検索) [継承]
PMID (任意): 11944908    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000175171800027 [継承]
Scopus (任意): 2-s2.0-0036290067 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, 3-18-15 Kuramoto, Tokushima, 770-8504, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Satoshi Hino, Hitoshi Kawamaha, Fumie Omotehara, Daisuke Uchida, Yoshihiro Miwa, NM Begum, Hideo Yoshida, Mitsunobu Sato and Takahiro Fujimori : Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells, Biochemical and Biophysical Research Communications, Vol.292, No.4, 957-963, 2002.
欧文冊子 ● Satoshi Hino, Hitoshi Kawamaha, Fumie Omotehara, Daisuke Uchida, Yoshihiro Miwa, NM Begum, Hideo Yoshida, Mitsunobu Sato and Takahiro Fujimori : Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells, Biochemical and Biophysical Research Communications, Vol.292, No.4, 957-963, 2002.

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