| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.分子酵素学研究センター (〜2007年3月31日/->組織[徳島大学.疾患酵素学研究センター])
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| ○著者 (必須): | 1. | 松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Yamada Takuji (日) (読)
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| 3. | (英) Yoshinaga K. Steven (日) (読)
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| 4. | (英) Boone Tom (日) (読)
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| 5. | (英) Horan Tom (日) (読)
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| 6. | (英) Fujita Shigeru (日) (読)
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| 7. | (英) Li Yi (日) (読)
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| 8. | (英) Mitani Tasuku (日) (読)
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| ○題名 (必須): | □ | (英) Essential role of NF-kappaB-inducing kinase in T cell activation through the TCR/CD3 pathway (日)
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| ○要約 (任意): | □ | (英) NF-kappa B-inducing kinase (NIK) is involved in lymphoid organogenesis in mice through lymphotoxin-beta receptor signaling. To clarify the roles of NIK in T cell activation through TCR/CD3 and costimulation pathways, we have studied the function of T cells from aly mice, a strain with mutant NIK. NIK mutant T cells showed impaired proliferation and IL-2 production in response to anti-CD3 stimulation, and these effects were caused by impaired NF-kappa B activity in both mature and immature T cells; the impaired NF-kappa B activity in mature T cells was also associated with the failure of maintenance of activated NF-kappa B. In contrast, responses to costimulatory signals were largely retained in aly mice, suggesting that NIK is not uniquely coupled to the costimulatory pathways. When NIK mutant T cells were stimulated in the presence of a protein kinase C (PKC) inhibitor, proliferative responses were abrogated more severely than in control mice, suggesting that both NIK and PKC control T cell activation in a cooperative manner. We also demonstrated that NIK and PKC are involved in distinct NF-kappa B activation pathways downstream of TCR/CD3. These results suggest critical roles for NIK in setting the threshold for T cell activation, and partly account for the immunodeficiency in aly mice. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) I-kappa B Kinase (日) (読)
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| 3. | (英) Interleukin-2 (日) (読)
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| 4. | (英) Lymphocyte Activation (日) (読)
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| 5. | (英) Mice (日) (読)
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| 6. | (英) NF-kappa B (日) (読)
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| 7. | (英) Protein Kinase C (日) (読)
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| 8. | (英) Protein-Serine-Threonine Kinases (日) (読)
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| 9. | (英) Proto-Oncogene Proteins (日) (読)
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| 10. | (英) Receptor-CD3 Complex, Antigen, T-Cell (日) (読)
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| 11. | (英) T-Lymphocytes (日) (読)
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| 12. | (英) Tetradecanoylphorbol Acetate (日) (読)
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| 13. | (英) Transcription Factors (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
| ○ISSN (任意): | □ | 0022-1767
ISSN: 0022-1767
(pISSN: 0022-1767, eISSN: 1550-6606) Title: Journal of immunology (Baltimore, Md. : 1950)Title(ISO): J ImmunolPublisher: American Association of Immunologists (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 169
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 1151 1158
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2002年 8月 1日 (平成 14年 8月 1日)
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| ○URL (任意): |
| ○DOI (任意): |
| ○PMID (任意): | □ | 12133934 (→Scopusで検索)
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| ○NAID (任意): |
| ○WOS (任意): | □ | 000177025100002
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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