| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究)
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 山本 圭 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生命科学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命コース])
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| 2. | 三木 寿美 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.創薬理論化学]/[徳島大学.フォトニクス健康フロンティア研究院])
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| 3. | (英) Sato Hiroyasu (日) (読)
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| 4. | (英) Nishito Yasumasa (日) (読)
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| 5. | (英) Gelb Michael H. (日) (読)
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| 6. | (英) Taketomi Yoshitaka (日) (読)
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| 7. | (英) Murakami Makoto (日) (読)
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| ○題名 (必須): | □ | (英) Expression and function of group IIE phospholipase A2 in mouse skin (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Recent studies using knock-out mice for various secreted phospholipase A2 (sPLA2) isoforms have revealed their non-redundant roles in diverse biological events. In the skin, group IIF sPLA2 (sPLA2-IIF), an "epidermal sPLA2" expressed in the suprabasal keratinocytes, plays a fundamental role in epidermal-hyperplasic diseases such as psoriasis and skin cancer. In this study, we found that group IIE sPLA2 (sPLA2-IIE) was expressed abundantly in hair follicles and to a lesser extent in basal epidermal keratinocytes in mouse skin. Mice lacking sPLA2-IIE exhibited skin abnormalities distinct from those in mice lacking sPLA2-IIF, with perturbation of hair follicle ultrastructure, modest changes in the steady-state expression of a subset of skin genes, and no changes in the features of psoriasis or contact dermatitis. Lipidomics analysis revealed that sPLA2-IIE and -IIF were coupled with distinct lipid pathways in the skin. Overall, two skin sPLA2s, hair follicular sPLA2-IIE and epidermal sPLA2-IIF, play non-redundant roles in distinct compartments of mouse skin, underscoring the functional diversity of multiple sPLA2s in the coordinated regulation of skin homeostasis and diseases. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Dermatitis, Contact (日) (読)
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| 3. | (英) Epidermis (日) (読)
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| 4. | (英) Gene Expression Regulation, Enzymologic (日) (読)
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| 5. | (英) Group II Phospholipases A2 (日) (読)
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| 6. | (英) Hair Follicle (日) (読)
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| 7. | (英) Mice (日) (読)
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| 8. | (英) Mice, Knockout (日) (読)
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| 9. | (英) Psoriasis (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)
| ○ISSN (任意): | □ | 0021-9258
ISSN: 0021-9258
(pISSN: 0021-9258, eISSN: 1083-351X) Title: The Journal of biological chemistryTitle(ISO): J Biol ChemPublisher: American Society for Biochemistry and Molecular Biology (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 291
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| ○号 (必須): | □ | 30
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| ○頁 (必須): | □ | 15602 15613
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 5月 23日 (平成 28年 5月 23日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1074/jbc.M116.734657 (→Scopusで検索)
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| ○PMID (任意): | □ | 27226633 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-84979300102
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| ○備考 (任意): | 1. | (英) Derived from Scopus.AUID(36096894600) (日)
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| 2. | (英) Modified using PubMed.PMID(27226633) (日)
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