『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=456874EID:456874, Map:0, LastModified:2026年3月9日(月) 14:49:33, Operator:[大家 隆弘], Avail:TRUE, Censor:承認済, Owner:[三木 寿美], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨):
○共著種別 (推奨): □国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究) [継承]
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1.三木 寿美 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.創薬理論化学]/[徳島大学.フォトニクス健康フロンティア研究院])
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2. (英) Kidoguchi Yuh (日) (読)
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3. (英) Sato Mariko (日) (読)
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4. (英) Taketomi Yoshitaka (日) (読)
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5. (英) Taya Choji (日) (読)
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6. (英) Muramatsu Kazuaki (日) (読)
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7. (英) Gelb Michael H. (日) (読)
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8.山本 圭 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生命科学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命コース])
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9. (英) Murakami Makoto (日) (読)
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○題名 (必須): □(英) Dual roles of group IID phospholipase A2 in inflammation and cancer  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) Phospholipase A2 enzymes have long been implicated in the promotion of inflammation by mobilizing pro-inflammatory lipid mediators, yet recent evidence suggests that they also contribute to anti-inflammatory or pro-resolving programs. Group IID-secreted phospholipase A2 (sPLA2-IID) is abundantly expressed in dendritic cells in lymphoid tissues and resolves the Th1 immune response by controlling the steady-state levels of anti-inflammatory lipids such as docosahexaenoic acid and its metabolites. Here, we show that psoriasis and contact dermatitis were exacerbated in Pla2g2d-null mice, whereas they were ameliorated in Pla2g2d-overexpressing transgenic mice, relative to littermate wild-type mice. These phenotypes were associated with concomitant alterations in the tissue levels of ω3 polyunsaturated fatty acid (PUFA) metabolites, which had the capacity to reduce the expression of pro-inflammatory and Th1/Th17-type cytokines in dendritic cells or lymph node cells. In the context of cancer, however, Pla2g2d deficiency resulted in marked attenuation of skin carcinogenesis, likely because of the augmented anti-tumor immunity. Altogether, these results underscore a general role of sPLA2-IID as an immunosuppressive sPLA2 that allows the microenvironmental lipid balance toward an anti-inflammatory state, exerting beneficial or detrimental impact depending upon distinct pathophysiological contexts in inflammation and cancer.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Fatty Acids, Omega-3 (日) (読) [継承]
3. (英) Group II Phospholipases A2 (日) (読) [継承]
4. (英) Immunity, Cellular (日) (読) [継承]
5. (英) Inflammation (日) (読) [継承]
6. (英) Mice (日) (読) [継承]
7. (英) Mice, Knockout (日) (読) [継承]
8. (英) Neoplasm Proteins (日) (読) [継承]
9. (英) Skin Neoplasms (日) (読) [継承]
10. (英) Th1 Cells (日) (読) [継承]
11. (英) Th17 Cells (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

○ISSN (任意): □0021-9258
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □291 [継承]
○号 (必須): □30 [継承]
○頁 (必須): □15588 15601 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2016年 5月 21日 (平成 28年 5月 21日) [継承]
○URL (任意):
○DOI (任意): □10.1074/jbc.M116.734624    (→Scopusで検索) [継承]
○PMID (任意): □27226632    (→Scopusで検索) [継承]
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○Scopus (任意): 1.2-s2.0-84978946086 [継承]
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○備考 (任意): 1.(英) Derived from Scopus.AUID(36096894600)  (日)    [継承]
2.(英) Modified using PubMed.PMID(27226632)  (日)    [継承]

標準的な表示

和文冊子 ● Yoshimi Miki, Yuh Kidoguchi, Mariko Sato, Yoshitaka Taketomi, Choji Taya, Kazuaki Muramatsu, H. Michael Gelb, Kei Yamamoto and Makoto Murakami : Dual roles of group IID phospholipase A2 in inflammation and cancer, The Journal of Biological Chemistry, 291, 30, 15588-15601, 2016.
欧文冊子 ● Yoshimi Miki, Yuh Kidoguchi, Mariko Sato, Yoshitaka Taketomi, Choji Taya, Kazuaki Muramatsu, H. Michael Gelb, Kei Yamamoto and Makoto Murakami : Dual roles of group IID phospholipase A2 in inflammation and cancer, The Journal of Biological Chemistry, 291, 30, 15588-15601, 2016.

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