| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない))
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| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Tuan Anh Pham (日) Pham Anh Tuan (読) ふぁん あん とん
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
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| 2. | 坂井 隆志
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| 3. | (英) Huy Van Dang (日) Dang Van Huy (読) だん ゔぁん ふぃ
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | (英) (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
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| 5. | (英) Diem Hong Tran (日) Tran Hong Diem (読) ちゃん ほん でぃえむ
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 6. | 宍戸 裕二 ([徳島大学.フォトニクス健康フロンティア研究院])
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| ○学籍番号 (推奨): |
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| 7. | チャン ホアンナム ([徳島大学.国際センター])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 8. | 福井 清 ([徳島大学.事務局.研究・産学連携部])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Nucling, a stress-inducible protein associated with apoptosomes, is important for microglial polarization/activation in the brain neuroinflamation (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Microglia, the central nervous system's resident macrophages, are critical for immune defense, protecting neurons during infection. Their role in postnatal brain development, particularly after injury, remains unclear. Nucling, a protein up-regulated during cardiac muscle differentiation, regulates NF-κB, influencing apoptosis and cell proliferation. In this study, we examined the role of Nucling in microglial activation using wild-type (WT) and Nucling-knockout (KO) neonatal mice subjected to poly(I:C), a viral mimic. Poly(I:C) treatment increased Iba1-positive microglia in both genotypes; however, KO mice showed a significantly exaggerated response in both cortical and hippocampal regions. Furthermore, while pro-inflammatory M1 markers (iNOS, CD86, TNFα, IL-6) were upregulated in both WT and KO mice, the anti-inflammatory M2 marker Arginase 1 (Arg1) was induced in WT but significantly suppressed in KO mice, indicating impaired M2 polarization. These findings suggest Nucling is essential for maintaining microglial polarization, supporting immunological processes against pathogens, and aiding central nervous system development. (日)
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| ○キーワード (推奨): | 1. | (英) M1/M2 phenotype (日) (読)
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| 2. | (英) microglia (日) (読)
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| 3. | (英) neuroinflammation (日) (読)
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| 4. | ヌクリング (nucling)
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| ○発行所 (推奨): | □ | (英) Oxford Academic (日) (読)
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| ○誌名 (必須): | □ | The Journal of Biochemistry ([日本生化学会])
(pISSN: 0021-924X, eISSN: 1756-2651)
| ○ISSN (任意): | □ | 1756-2651
ISSN: 0021-924X
(pISSN: 0021-924X, eISSN: 1756-2651) Title: Journal of biochemistryTitle(ISO): J BiochemSupplier: Oxford University PressPublisher: Oxford University Press (NLM Catalog)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 178
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 391 402
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2025年 12月 2日 (令和 7年 12月 2日)
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| ○URL (任意): | □ | https://academic.oup.com/jb/advance-article/doi/10.1093/jb/mvaf055/8250343?
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| ○DOI (任意): | □ | 10.1093/jb/mvaf055 (→Scopusで検索)
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| ○PMID (任意): | □ | 40926612 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | https://www.scopus.com/pages/publications/105023850770
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| ○researchmap (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): | 1. | 福井 清 ([徳島大学.事務局.研究・産学連携部])
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| ○備考 (任意): | 1. | (英) Article.ELocationID: mvaf055 (日)
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| 2. | (英) Article.ELocationID: 10.1093/jb/mvaf055 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: M1/M2 phenotype (日)
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| 5. | (英) KeywordList.Keyword: Microglia (日)
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| 6. | (英) KeywordList.Keyword: Nucling (日)
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| 7. | (英) KeywordList.Keyword: neuroinflammation (日)
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