| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない))
| [継承] |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 鹿草 宏 ([徳島大学.病院.中央診療施設等.地域脳神経外科診療部])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Izumi Yamaguchi (日) (読)
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| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Kenji Shono (日) 庄野 健児 (読) しょうの けんじ
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 4. | (英) Yoshifumi Mizobuchi (日) 溝渕 佳史 (読) みぞぶち よしふみ
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 5. | (英) Eiji Shikata (日) 四方 英二 (読) しかた えいじ
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
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| 6. | 松田 拓 ([徳島大学.大学院医歯薬学研究部.医学域.特定研究部門.教育支援系.医学教育支援])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 7. | 宮本 健志 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | 原 慶次郎 ([徳島大学.病院.中央診療施設等.地域脳神経外科診療部])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | (英) Keiko T Kitazato (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 10. | 宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命コース])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 11. | (英) Yasuhisa Kanematsu (日) 兼松 康久 (読) かねまつ やすひさ
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 12. | 髙木 康志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Differences in amyloid-β and tau/p-tau deposition in blood-injected mouse brains using micro-syringe to mimic traumatic brain microhemorrhages (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Cerebral microbleeds (CMBs) due to traumatic brain injuries (TBI) have been shown to lead to cognitive decline and impairment. CMBs caused by TBI may be associated with pathophysiological mechanisms involving inflammation and the accumulation of amyloid-β (Aβ), tau, and phosphorylated tau (p-tau), contributing to cognitive abnormalities. However, their relationships remain unclear. To test our hypothesis that Aβ, tau, and p-tau are accumulated and regulated separately in mice with injuries imitating CMBs from TBI, we studied. Seven-week-old C57BL/6 male mice were injected with 15 μL of heparinized autologous blood or saline by micro-syringe into the front lobe. Expression profiles and regulation of Aβ, tau, and p-tau were assessed immunohistochemically over time. On day 7 after blood injection, Iba-1 and S100B cells in damaged cortex adjacent to the injection site were higher than saline injection group and non-injected sham. On days 3-14, Aβ deposition were gradually increased but normalized by day 28. In contrast, tau/p-tau deposition gradually increased during days 14-28 and dispersed along the corticomedullary junction adjacent to hem deposits, indicating different expression profiles from Aβ. Deposits of Aβ, but not tau/p-tau, were phagocytosed by CD163 macrophages increased by Gc-protein macrophage-activating factor during days 7-28, suggesting different mechanisms of deposition and regulation between Aβ and tau/p-tau. Deposition and regulation differ between Aβ and tau/p-tau in mice with injuries mimicking CMBs from TBI. Further clarification of relationships between the pathologies of cognitive impairment and their neurodegenerative consequences is needed. (日)
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| ○キーワード (推奨): | 1. | (英) Amyloid-β (日) (読)
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| 2. | (英) Cognitive impairment (日) (読)
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| 3. | (英) Tauopathy (日) (読)
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| 4. | (英) Traumatic cerebral microbleed (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Chemical Neuroanatomy ([Elsevier])
(pISSN: 0891-0618, eISSN: 1873-6300)
| ○ISSN (任意): | □ | 1873-6300
ISSN: 0891-0618
(pISSN: 0891-0618, eISSN: 1873-6300) Title: Journal of chemical neuroanatomyTitle(ISO): J Chem NeuroanatPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 130
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 102258 102258
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2023年 3月 15日 (令和 5年 3月 15日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.jchemneu.2023.102258 (→Scopusで検索)
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| ○PMID (任意): | □ | 36925083 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.jchemneu.2023.102258 (日)
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| 2. | (英) Article.ELocationID: S0891-0618(23)00028-5 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 5. | (英) KeywordList.Keyword: Amyloid-β (日)
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| 6. | (英) KeywordList.Keyword: Cognitive impairment (日)
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| 7. | (英) KeywordList.Keyword: Tauopathy (日)
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| 8. | (英) KeywordList.Keyword: Traumatic cerebral microbleed (日)
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