| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | (英) Munkhjargal Batkhishig (日) Batkhishig Munkhjargal (読) ばとひしぐ むんふじゃらがる
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 近藤 和也
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| 3. | (英) Shiho Soejima (日) 副島 志帆 (読) そえじま しほ
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| ○学籍番号 (推奨): | □ | ****
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| 4. | (英) Bilguun Tegshee (日) BILGUUN TEGSHEE (読) びるぐん てぐし
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| ○学籍番号 (推奨): | □ | ****
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| 5. | 髙井 チカ子
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| ○学籍番号 (推奨): | □ | ****
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| 6. | 河北 直也 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学]/[徳島大学.病院.診療科.外科.呼吸器外科])
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| 7. | 鳥羽 博明 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.看護学系.臨床腫瘍医療学])
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| 8. | 滝沢 宏光 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学]/[徳島大学.病院.診療科.外科.呼吸器外科])
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| ○題名 (必須): | □ | (英) Aberrant methylation of dipeptidyl peptidaselike 6 as a potential prognostic biomarker for lung adenocarcinoma (日)
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| ○要約 (任意): | □ | (英) We previously performed the genome-wide screening of aberrantly methylated CpG islands (CGIs) using the paired tumorous and non-tumorous tissues of 12 lung adenocarcinomas (LADC). In comparisons with paired normal lung tissues, dipeptidyl peptidase-like 6 () has been identified as the most significantly hypermethylated CGI in LADC. is a protein that modulates A-type potassium channels in the somatodendritic compartments of neurons, which play a role in synaptic plasticity. Previous studies have showed that is downregulated in cancers, such as acute myeloid leukemia and melanoma, but upregulated in colon cancer, which is attributed to hyper- and hypomethylation, respectively. The present study investigated the methylation and expression levels of and its prognostic value in patients with LADC. The DNA methylation and mRNA expression levels of in surgically resected LADC tissues were examined by bisulfite pyrosequencing and reverse transcription-quantitative PCR, respectively. The DNA methylation and mRNA expression levels of were both significantly higher in LADC tissues compared with in normal lung tissues (n=25; P<0.0001). Overall and disease-free survival rates were significantly higher in LADC with high mRNA expression levels compared with those with low levels. In conclusion, epigenetic alterations in were significantly higher in LADC tissues compared with in normal lung tissues, which may contribute to the malignant features and worse prognosis of these patients. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Oncology Letters (Spandidos Publications)
(pISSN: 1792-1074, eISSN: 1792-1082)
| ○ISSN (任意): | □ | 1792-1082
ISSN: 1792-1074
(pISSN: 1792-1074, eISSN: 1792-1082) Title: Oncology lettersTitle(ISO): Oncol LettPublisher: Spandidos Publications (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 25
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 206 206
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| ○年月日 (必須): | □ | 西暦 2023年 3月 初日 (令和 5年 3月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3892/ol.2023.13792 (→Scopusで検索)
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| ○PMID (任意): | □ | 37123021 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 206 (日)
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| 2. | (英) Article.ELocationID: 10.3892/ol.2023.13792 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: DNA methylation (日)
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| 5. | (英) KeywordList.Keyword: DPP6 (日)
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| 6. | (英) KeywordList.Keyword: lung cancer (日)
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| 7. | (英) KeywordList.Keyword: mRNA expression (日)
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| 8. | (英) KeywordList.Keyword: prognosis (日)
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| 9. | (英) CoiStatement: All authors declare that they have no competing interests. (日)
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