| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない))
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| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Uemura Yuta (日) 植村 勇太 (読) うえむら ゆうた
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
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| 2. | 木下 倫子 ([徳島大学.病院.診療科.脳·神経·精神科.麻酔科])
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| 3. | 酒井 陽子 ([徳島大学.病院.中央診療施設等.麻酔科診療部])
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| 4. | 田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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| ○題名 (必須): | □ | (英) Hemodynamic impact of ephedrine on hypotension during general anesthesia: a prospective cohort study on middle-aged and older patients (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Ephedrine is a mixed α- and β-agonist vasopressor that is frequently used for the correction of hypotension during general anesthesia. β-responsiveness has been shown to decrease with age; therefore, this study aimed to determine whether aging would reduce the pressor effect of ephedrine on hypotension during general anesthesia. Seventy-five patients aged ≥ 45 years were included in this study, with 25 patients allocated to each of the three age groups: 45-64 years, 65-74 years, and ≥ 75 years. All patients received propofol, remifentanil, and rocuronium for the induction of general anesthesia, followed by desflurane and remifentanil. Cardiac output (CO) was estimated using esCCO technology. Ephedrine (0.1 mg/kg) was administered for the correction of hypotension. The primary and secondary outcome measures were changes in the mean arterial pressure (MAP) and CO, respectively, at 5 min after the administration of ephedrine. RESULTS: The administration of ephedrine significantly increased MAP (p < 0.001, mean difference: 8.34 [95% confidence interval (CI), 5.95-10.75] mmHg) and CO (p < 0.001, mean difference: 7.43 [95% CI, 5.20-9.65] %) across all groups. However, analysis of variance revealed that the degree of elevation of MAP (F [2, 72] = 0.546, p = 0.581, η = 0.015 [95% CI, 0.000-0.089]) and CO (F [2, 72] = 2.023, p = 0.140, η = 0.053 [95% CI, 0.000-0.162]) did not differ significantly among the groups. Similarly, Spearman's rank correlation and multiple regression analysis revealed no significant relation between age and the changes in MAP or CO after the administration of ephedrine. The administration of ephedrine significantly increased MAP and CO; however, no significant correlation with age was observed in patients aged > 45 years. These findings suggest that ephedrine is effective for the correction of hypotension during general anesthesia, even in elderly patients. UMIN-CTR (UMIN000045038; 02/08/2021). (日)
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| ○キーワード (推奨): | 1. | (英) Aged (日) (読)
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| 2. | (英) Middle Aged (日) (読)
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| 3. | (英) Humans (日) (読)
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| 4. | (英) Ephedrine (日) (読)
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| 5. | (英) Prospective Studies (日) (読)
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| 6. | (英) Remifentanil (日) (読)
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| 7. | (英) Hemodynamics (日) (読)
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| 8. | (英) Hypotension (日) (読)
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| 9. | (英) Vasoconstrictor Agents (日) (読)
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| 10. | (英) Anesthesia, General (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | BMC Anesthesiology ([BioMed Central Ltd.])
(eISSN: 1471-2253)
| ○ISSN (任意): | □ | 1471-2253
ISSN: 1471-2253
(eISSN: 1471-2253) Title: BMC anesthesiologyTitle(ISO): BMC AnesthesiolPublisher: BioMed Central (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 23
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 283 283
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2023年 8月 22日 (令和 5年 8月 22日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1186/s12871-023-02244-4 (→Scopusで検索)
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| ○PMID (任意): | □ | 37608253 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85168706206
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): | 1. | 木下 倫子 ([徳島大学.病院.診療科.脳·神経·精神科.麻酔科])
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1186/s12871-023-02244-4 (日)
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| 2. | (英) Article.DataBankList.DataBank.DataBankName: JPRN (日)
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| 3. | (英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: UMIN000045038 (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 5. | (英) KeywordList.Keyword: Aging (日)
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| 6. | (英) KeywordList.Keyword: Elderly (日)
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| 7. | (英) KeywordList.Keyword: Ephedrine (日)
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| 8. | (英) KeywordList.Keyword: Hemodynamics (日)
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| 9. | (英) KeywordList.Keyword: Hypotension (日)
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