| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Sugita Erina (日) (読)
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| 2. | (英) Sonoda Homare (日) (読)
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| 3. | (英) Ryuzaki Masaki (日) (読)
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| 4. | (英) Hashiguchi Akinori (日) (読)
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| 5. | (英) Tokuyama Hirobumi (日) (読)
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| 6. | 𦚰野 修 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.腎臓内科学])
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| 7. | (英) Kanda Takeshi (日) (読)
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| 8. | (英) Itoh Hiroshi (日) (読)
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| ○題名 (必須): | □ | (英) Diagnosis of monoclonal immunotactoid glomerulopathy with positive λ chain by immunoelectron microscopy. (日)
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| ○要約 (任意): | □ | (英) We report the case of a 73-year-old-man who developed immunotactoid glomerulopathy (ITG). ITG is a rare disease characterized by proliferative glomerulonephritis and capillary wall deposits with a 10-60 nm diameter microtubular substructure. In monoclonal ITG, immunofluorescence analysis typically exhibits IgG with light chain restriction. Recent reviews recommend distinguishing monoclonal ITG from polyclonal ITG because monoclonal ITG is associated with a higher incidence of hematological disorders and better responsiveness to clone-directed therapy and renal prognosis. In our case, IgG, IgA, and IgM were negative by routine immunofluorescence; however, immunoelectron microscopy revealed positive λ chain. At 6 months after renal biopsy, the IgG λ chain was detected in the serum and urine, reflecting possible monoclonality. Therefore, it is useful to perform immunoelectron microscopy and follow-up with serum and urine protein electrophoresis and immunofixation to diagnose monoclonal ITG, even when routine immunofluorescence shows negative or nonspecific findings. (日)
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| ○キーワード (推奨): | 1. | (英) Humans (日) (読)
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| 2. | (英) Aged (日) (読)
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| 3. | (英) Microscopy, Immunoelectron (日) (読)
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| 4. | (英) Glomerulonephritis (日) (読)
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| 5. | (英) Kidney (日) (読)
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| 6. | (英) Prognosis (日) (読)
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| 7. | (英) Immunoglobulin G (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | CEN Case Reports ([Springer-Verlag.シュプリンガー ジャパン])
(eISSN: 2192-4449)
| ○ISSN (任意): | □ | 2192-4449
ISSN: 2192-4449
(eISSN: 2192-4449) Title: CEN case reportsTitle(ISO): CEN Case RepPublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 12
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 7 13
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 6月 14日 (令和 4年 6月 14日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s13730-022-00714-1 (→Scopusで検索)
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| ○PMID (任意): | □ | 35699924 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Case Reports (日)
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| 2. | (英) PublicationType: Journal Article (日)
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