| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | (英) Katanasaka Yasufumi (日) (読)
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| 2. | (英) Saito Ayumi (日) (読)
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| 3. | (英) Sunagawa Yoichi (日) (読)
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| 4. | (英) Sari Nurmila (日) (読)
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| 5. | 船本 雅文 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学])
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| 6. | (英) Shimizu Satoshi (日) (読)
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| 7. | (英) Shimizu Kana (日) (読)
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| 8. | (英) Akimoto Takehide (日) (読)
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| 9. | (英) Ueki Chikara (日) (読)
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| 10. | (英) Kitano Mitsuru (日) (読)
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| 11. | (英) Hasegawa Koji (日) (読)
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| 12. | (英) Sakaguchi Genichi (日) (読)
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| 13. | (英) Morimoto Tatsuya (日) (読)
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| ○題名 (必須): | □ | (英) ANGPTL4 Expression Is Increased in Epicardial Adipose Tissue of Patients with Coronary Artery Disease. (日)
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| ○要約 (任意): | □ | (英) Epicardial adipose tissue (EAT) is known to affect atherosclerosis and coronary artery disease (CAD) pathogenesis, persistently releasing pro-inflammatory adipokines that affect the myocardium and coronary arteries. Angiopoietin-like 4 (ANGPTL4) is a protein secreted from adipose tissue and plays a critical role in the progression of atherosclerosis. Here, the expression of ANGPTL4 in EAT was investigated in CAD subjects. Thirty-four consecutive patients (13 patients with significant CAD; 21 patients without CAD) undergoing elective open-heart surgery were recruited. EAT and pericardial fluid were obtained at the time of surgery. mRNA expression and ANGPTL4 and IL-1β levels were evaluated by qRT-PCR and ELISA. The expression of ANGPTL4 (p = 0.0180) and IL-1β (p < 0.0001) in EAT significantly increased in the CAD group compared to that in the non-CAD group and positively correlated (p = 0.004). Multiple regression analysis indicated that CAD is a contributing factor for ANGPTL4 expression in EAT. IL-1β level in the pericardial fluid was significantly increased in patients with CAD (p = 0.020). Moreover, the expression of ANGPTL4 (p = 0.004) and IL-1β (p < 0.001) in EAT was significantly increased in non-obese patients with CAD. In summary, ANGPTL4 expression in EAT was increased in CAD patients. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Journal of Clinical Medicine (MDPI AG)
(eISSN: 2077-0383)
| ○ISSN (任意): | □ | 2077-0383
ISSN: 2077-0383
(eISSN: 2077-0383) Title: Journal of clinical medicineTitle(ISO): J Clin MedPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 11
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | 2449 2449
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 4月 27日 (令和 4年 4月 27日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/jcm11092449 (→Scopusで検索)
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| ○PMID (任意): | □ | 35566578 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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