『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=398897EID:398897, Map:0, LastModified:2023年7月27日(木) 10:54:51, Operator:[船本 雅文], Avail:TRUE, Censor:承認済, Owner:[船本 雅文], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
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○著者 (必須): 1. (英) Sunagawa Yoichi (日) (読)
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2. (英) Katayama Ayumi (日) (読)
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3.船本 雅文 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.薬理学])
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4. (英) Shimizu Kana (日) (読)
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5. (英) Shimizu Satoshi (日) (読)
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6. (英) Sari Nurmila (日) (読)
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7. (英) Katanasaka Yasufumi (日) (読)
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8. (英) Miyazaki Yusuke (日) (読)
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9. (英) Hosomi Ryota (日) (読)
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10. (英) Hasegawa Koji (日) (読)
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11. (英) Morimoto Tatsuya (日) (読)
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○題名 (必須): □(英) The polyunsaturated fatty acids, EPA and DHA, ameliorate myocardial infarction-induced heart failure by inhibiting p300-HAT activity in rats.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) While the cardioprotective functions of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and omega-3 unsaturated fatty acids have been previously demonstrated, little is known about their effects on cardiomyocyte hypertrophy. In this study, we compared the effects of EPA and DHA on hypertrophic responses in cardiomyocytes and development of heart failure in rats with myocardial infarction (MI). Both EPA and DHA significantly suppressed phenylephrine- and p300-induced cardiomyocyte hypertrophy, transcription of hypertrophy response genes, and acetylation of histone H3K9 in cardiomyocytes. EPA and DHA directly inhibited p300-histone acetyltransferase activity (IC50: 37.8 and 30.6 μM, respectively). Further, EPA- and DHA-induced allosteric inhibition of histones and competitive inhibition of acetyl-CoA, and significantly prevented p300-induced hypertrophic responses. Rats with moderate MI (left ventricular fractional shortening [FS] <40%) were randomly assigned to three groups, namely, vehicle (saline), EPA (1 g/kg), and DHA (1 g/kg). One week after the operation, rats were orally administrated with test agents for 6 weeks. Echocardiographic analysis demonstrated that both EPA and DHA treatments preserved FS and prevented MI-induced left ventricular remodeling. Furthermore, EPA and DHA significantly suppressed the MI-induced increase in myocardial cell diameter, perivascular fibrosis, mRNA levels of hypertrophic markers, fibrosis, and acetylation of histone H3K9. The effects on hypertrophic responses and the development of heart failure were not different between EPA and DHA groups. Both EPA and DHA suppressed hypertrophic responses and the development of heart failure to the same extent through the inhibition of p300-HAT activity.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Docosahexaenoic Acids (日) (読) [継承]
3. (英) Eicosapentaenoic Acid (日) (読) [継承]
4. (英) Fibrosis (日) (読) [継承]
5.心不全 (heart failure) [継承]
6. (英) Histones (日) (読) [継承]
7. (英) Hypertrophy (日) (読) [継承]
8. (英) Myocardial Infarction (日) (読) [継承]
9. (英) Rats (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □The Journal of Nutritional Biochemistry ([Elsevier])
(pISSN: 0955-2863, eISSN: 1873-4847)

○ISSN (任意): □1873-4847
ISSN: 0955-2863 (pISSN: 0955-2863, eISSN: 1873-4847)
Title: The Journal of nutritional biochemistry
Title(ISO): J Nutr Biochem
Publisher: Elsevier Inc.
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □106 [継承]
○号 (必須): □ [継承]
○頁 (必須): □109031 109031 [継承]
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○年月日 (必須): □西暦 2022年 4月 30日 (令和 4年 4月 30日) [継承]
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○DOI (任意): □10.1016/j.jnutbio.2022.109031    (→Scopusで検索) [継承]
○PMID (任意): □35504444    (→Scopusで検索) [継承]
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○備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yoichi Sunagawa, Ayumi Katayama, Masafumi Funamoto, Kana Shimizu, Satoshi Shimizu, Nurmila Sari, Yasufumi Katanasaka, Yusuke Miyazaki, Ryota Hosomi, Koji Hasegawa and Tatsuya Morimoto : The polyunsaturated fatty acids, EPA and DHA, ameliorate myocardial infarction-induced heart failure by inhibiting p300-HAT activity in rats., The Journal of Nutritional Biochemistry, 106, 109031, 2022.
欧文冊子 ● Yoichi Sunagawa, Ayumi Katayama, Masafumi Funamoto, Kana Shimizu, Satoshi Shimizu, Nurmila Sari, Yasufumi Katanasaka, Yusuke Miyazaki, Ryota Hosomi, Koji Hasegawa and Tatsuya Morimoto : The polyunsaturated fatty acids, EPA and DHA, ameliorate myocardial infarction-induced heart failure by inhibiting p300-HAT activity in rats., The Journal of Nutritional Biochemistry, 106, 109031, 2022.

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