| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.ゲノム機能研究センター (〜2008年3月31日/->組織[徳島大学.疾患プロテオゲノム研究センター])
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| ○著者 (必須): | 1. | 森谷 眞紀 (香川小児病院)
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| ○学籍番号 (推奨): |
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| 2. | (英) Togawa Katsuhiko (日) (読)
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| ○学籍番号 (推奨): |
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| 3. | (英) Yaguchi Hiroshi (日) (読)
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| 4. | (英) Fujita Yuka (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | 長﨑 裕加 (徳島大学医歯薬学研究部・医薬品情報学分野)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 6. | 井上 寛
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 7. | 鎌谷 直之 ([徳島大学.ゲノム機能研究センター])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 8. | 板倉 光夫
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| ○題名 (必須): | □ | (英) Identification of diabetes susceptibility loci in db mice by combined quantitative trait loci analysis and haplotype mapping. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) To identify the disease-susceptibility genes of type 2 diabetes, we performed quantitative trait loci (QTL) analysis in F(2) populations generated from a BKS.Cg-m+/+Lepr(db) and C3H/HeJ intercross, taking advantage of genetically determined obesity and diabetes traits associated with the db gene. A genome-wide scan in the F(2) populations divided by sex and db genotypes identified 14 QTLs in total and 3 major QTLs on chromosome (Chr) 3 (LOD 5.78) for fat pad weight, Chr 15 (LOD 6.64) for body weight, and Chr 16 (LOD 8.15) for blood glucose concentrations. A linear-model-based genome scan using interactive covariates allowed us to consider sex- or sex-by db-specific effects of each locus. For the most significant QTL on Chr 16, the high-resolution haplotype comparison between BKS and C3H strains reduced the critical QTL interval from 20 to 4.6 Mb by excluding shared haplotype regions and identified 11 nonsynonymous single-nucleotide polymorphisms in six candidate genes. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Chromosome Mapping (日) (読)
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| 3. | (英) Crosses, Genetic (日) (読)
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| 4. | (英) Diabetes Mellitus, Type 2 (日) (読)
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| 5. | (英) Disease Susceptibility (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | (英) Haplotypes (日) (読)
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| 8. | (英) Male (日) (読)
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| 9. | (英) Mice (日) (読)
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| 10. | (英) Mice, Inbred C3H (日) (読)
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| 11. | (英) Mice, Inbred C57BL (日) (読)
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| 12. | 肥満症 (obesity)
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| 13. | (英) Polymorphism, Single Nucleotide (日) (読)
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| 14. | (英) Quantitative Trait Loci (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Genomics ([Elsevier])
(pISSN: 0888-7543, eISSN: 1089-8646)
| ○ISSN (任意): | □ | 0888-7543
ISSN: 0888-7543
(pISSN: 0888-7543, eISSN: 1089-8646) Title: GenomicsTitle(ISO): GenomicsPublisher: Academic Press Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 88
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 719 730
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2006年 8月 17日 (平成 18年 8月 17日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.ygeno.2006.07.002 (→Scopusで検索)
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| ○PMID (任意): | □ | 16919419 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-33750957306
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Division of Genetic Information, Institute for Genome Research, The University of Tokushima, Tokushima 770-8503, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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