| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Yimamu Yilimulati (日) (読)
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| 2. | (英) Ohtani Ayako (日) (読)
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| 3. | (英) Takei Yuichiro (日) (読)
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| 4. | (英) Furuichi Airi (日) (読)
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| 5. | 亀井 優輝 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.食品栄養学]/[徳島大学.大学院医歯薬学研究部.医学域.先端基礎栄養学教育研究プロジェクト])
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| 6. | 奥村 仙示
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| 7. | 大南 博和
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| 8. | 増田 真志 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.臨床食管理学])
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| 9. | (英) Miyazaki Makoto (日) (読)
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| 10. | 山本 浩範
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| 11. | 竹谷 豊 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.臨床食管理学])
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| ○題名 (必須): | □ | (英) 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) induces ectopic calcification. (日)
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| ○要約 (任意): | □ | (英) Vascular calcification is an important pathogenesis related to cardiovascular disease and high mortality rate in chronic kidney disease (CKD) patients. It has been well-known that hyper-phosphatemia induces osteochondrogenic transition of vascular smooth muscle cells (VSMCs) resulting ectopic calcification in aortic media, cardiac valve, and kidney. However, the detailed mechanism of the ectopic calcification has been not clarified yet. Here, we found that the co-localization of CYP27B1 with the calcified lesions of aorta and arteries in kidney of klotho mutant () mice, and then investigated the role of CYP27B1 in the mineralization of the VSMCs. Under high phosphate condition, overexpression of CYP27B1 induced calcification and osteocalcin mRNA expression in the VSMCs. Inversely, siRNA- inhibited high phosphate-induced calcification of the VSMCs. We also found that the accumulated CYP27B1 protein was glycosylated in the kidney of mice. Therefore, overexpression of CYP27B1-N310A and CYP27B1-T439A, which are a mutation for -linked glycosylation site (N310A) and a mutation for -linked glycosylation site (T439A) in CYP27B1, decreased calcium deposition and expression of RUNX2 induced by high phosphate medium in VSMCs compared with wild-type CYP27B1. These results suggest that extra-renal expression of glycosylated CYP27B1 would be required for ectopic calcification of VSMCs under hyperphosphatemia. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Journal of Clinical Biochemistry and Nutrition (日本酸化ストレス学会)
(pISSN: 0912-0009, eISSN: 1880-5086)
| ○ISSN (任意): | □ | 0912-0009
ISSN: 0912-0009
(pISSN: 0912-0009, eISSN: 1880-5086) Title: Journal of clinical biochemistry and nutritionTitle(ISO): J Clin Biochem NutrSupplier: 一般社団法人 日本酸化ストレス学会Publisher: The Society for Free Radical Research Japan (NLM Catalog)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 71
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 103 111
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 6月 4日 (令和 4年 6月 4日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3164/jcbn.22-16 (→Scopusで検索)
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| ○PMID (任意): | □ | 36213783 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.3164/jcbn.22-16 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: arteriosclerosis (日)
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| 4. | (英) KeywordList.Keyword: bone and mineral disease (日)
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| 5. | (英) KeywordList.Keyword: chronic kidney disease (日)
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| 6. | (英) KeywordList.Keyword: dialysis (日)
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| 7. | (英) KeywordList.Keyword: hyperphosphatemia (日)
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| 8. | (英) KeywordList.Keyword: medial calcification (日)
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| 9. | (英) CoiStatement: No potential conflicts of interest were disclosed. The sponsors had no role in the study design, execution, interpretation of results, or writing of the manuscript. (日)
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