| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Yamamoto Shota (日) (読)
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| ○学籍番号 (推奨): |
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| 2. | 野口 拓樹 ([徳島大学.病院.中央診療施設等.周産母子センター])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | 武田 明日香 ([徳島大学.病院.中央診療施設等.ゲノム医療センター])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | 新垣 亮輔
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| 5. | 内芝 舞実
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| ○学籍番号 (推奨): |
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| 6. | (英) Imaizumi Junki (日) (読)
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| 7. | 湊 沙希
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| 8. | 鎌田 周平
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| [継承] |
| 9. | 香川 智洋
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| [継承] |
| 10. | 吉田 あつ子 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.中央診療施設等.周産母子センター])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 11. | (英) Kawakita Takako (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 12. | 山本 由理 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.中央診療施設等.周産母子センター]/[徳島大学.病院.診療科.小児·周産·女性科.産科婦人科])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 13. | 吉田 加奈子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 14. | (英) Kon Masafumi (日) (読)
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| [継承] |
| 15. | (英) Shinohara Nobuo (日) (読)
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| [継承] |
| 16. | 岩佐 武 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
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| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Polycystic ovary syndrome (PCOS) is frequently seen in females of reproductive age and is associated with metabolic disorders that are exacerbated by obesity. Although body weight reduction programs via diet and lifestyle changes are recommended for modifying reproductive and metabolic phenotypes, the drop-out rate is high. Thus, an efficacious, safe, and continuable treatment method is needed. Recent studies have shown that oxytocin (OT) reduces body weight gain and food intake, and promotes lipolysis in some mammals, including humans (especially obese individuals), without any adverse effects. In the present study, we evaluated the changes in endogenous OT levels, and the effects of acute and chronic OT administration on body weight changes, food intake, and fat mass using novel dihydrotestosterone-induced PCOS model rats. We found that the serum OT level was lower in PCOS model rats than in control rats, whereas the hypothalamic OT mRNA expression level did not differ between them. Acute intraperitoneal administration of OT during the dark phase reduced the body weight gain and food intake in PCOS model rats, but these effects were not observed in control rats. In contrast, chronic administration of OT decreased the food intake in both the PCOS model rats and control rats. These findings indicate that OT may be a candidate medicine that is efficacious, safe, and continuable for treating obese PCOS patients. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Body Weight (日) (読)
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| 3. | (英) Eating (日) (読)
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| 4. | 女性 (female)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Mammals (日) (読)
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| 7. | 肥満症 (obesity)
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| 8. | (英) Oxytocin (日) (読)
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| 9. | (英) Polycystic Ovary Syndrome (日) (読)
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| 10. | (英) Rats (日) (読)
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| 11. | (英) Weight Gain (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | International Journal of Molecular Sciences (Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(pISSN: 1661-6596, eISSN: 1422-0067)
| ○ISSN (任意): | □ | 1422-0067
ISSN: 1661-6596
(pISSN: 1661-6596, eISSN: 1422-0067) Title: International journal of molecular sciencesTitle(ISO): Int J Mol SciPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 23
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| ○号 (必須): | □ | 15
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| ○頁 (必須): | □ | 8207 8207
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 7月 26日 (令和 4年 7月 26日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/ijms23158207 (→Scopusで検索)
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| ○PMID (任意): | □ | 35897783 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-85135370141
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| ○researchmap (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 8207 (日)
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| 2. | (英) Article.ELocationID: 10.3390/ijms23158207 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: DHT (日)
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| 5. | (英) KeywordList.Keyword: PCOS (日)
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| 6. | (英) KeywordList.Keyword: body weight (日)
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| 7. | (英) KeywordList.Keyword: food intake (日)
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| 8. | (英) KeywordList.Keyword: metabolic (日)
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| 9. | (英) KeywordList.Keyword: oxytocin (日)
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| 10. | (英) CoiStatement: The authors declare no conflict of interest. (日)
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