| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Sun Luchuanyang (日) (読)
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| 2. | (英) Kim Sangeun (日) (読)
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| 3. | (英) Mori Ryoichi (日) (読)
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| 4. | (英) Miyaji Nobuyuki (日) (読)
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| 5. | 二川 健 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.生体栄養学])
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| 6. | 平坂 勝也
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| ○題名 (必須): | □ | (英) Astaxanthin Exerts Immunomodulatory Effect by Regulating SDH-HIF-1α Axis and Reprogramming Mitochondrial Metabolism in LPS-Stimulated RAW264.7 Cells. (日)
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| ○要約 (任意): | □ | (英) production and maintained the mitochondrial membrane potential, implying that AX preserved mitochondrial homeostasis to avoid LPS stimulation-induced mitochondrial dysfunction. Additionally, AX prevented the decrease in mitochondrial complexes I, II, and III, which were caused by LPS stimulation. Especially, AX inhibited the reduction in mitochondrial succinate dehydrogenase (SDH; complex II) activity and upregulated the protein and mRNA level of SDH complex, subunit B. Furthermore, AX blocked the IL-1β expression by regulating the SDH-HIF-1α axis and suppressed the energy shift from an OXPHOS phenotype to a glycolysis phenotype. These findings revealed important effects of AX on mitochondrial enzymes as well as on mitochondrial energy metabolism in the immune response. In addition, these raised the possibility that AX plays an important role in other diseases caused by SDH mutation and metabolic disorders. (日)
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| ○キーワード (推奨): | 1. | (英) Lipopolysaccharides (日) (読)
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| 2. | (英) Succinate Dehydrogenase (日) (読)
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| 3. | (英) Mitochondria (日) (読)
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| 4. | (英) Immunity (日) (読)
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| 5. | (英) Hypoxia-Inducible Factor 1, alpha Subunit (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Marine Drugs (Qingdao hai yang da xue/Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(eISSN: 1660-3397)
| ○ISSN (任意): | □ | 1660-3397
ISSN: 1660-3397
(eISSN: 1660-3397) Title: Marine drugsTitle(ISO): Mar DrugsPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 20
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| ○号 (必須): | □ | 11
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| ○頁 (必須): | □ | 660 660
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 10月 25日 (令和 4年 10月 25日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/md20110660 (→Scopusで検索)
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| ○PMID (任意): | □ | 36354983 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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