| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Yang Min (日) (読)
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| 2. | (英) Sun Luchuanyang (日) (読)
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| 3. | (英) Kawabata Yasunosuke (日) (読)
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| 4. | (英) Murayama Fumihito (日) (読)
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| 5. | (英) Maegawa Takahiro (日) (読)
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| 6. | 二川 健 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.生体栄養学])
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| 7. | (英) Hirasaka Katsuya (日) (読)
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| ○題名 (必須): | □ | (英) Balenine, Imidazole Dipeptide Promotes Skeletal Muscle Regeneration by Regulating Phagocytosis Properties of Immune Cells. (日)
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| ○要約 (任意): | □ | (英) Balenine is one of the endogenous imidazole dipeptides derived from marine products. It is composed of beta-alanine and 3-methyl-L-histidine, which exist mainly in the muscles of marine organisms. The physiological functions of dietary balenine are not well-known. In this study, we investigated whether the supplementation of dietary balenine was associated with muscle function in a cardiotoxin-indued muscle degeneration/regeneration model. Through morphological observation, we found that the supplementation of balenine-enriched extract promoted the regeneration stage. In addition, the expression of regeneration-related myogenic marker genes, such as paired box protein 7, MyoD1, myogenin, and Myh3, in a group of mice fed a balenine-enriched extract diet was higher than that in a group fed a normal diet. Moreover, the supplementation of balenine-enriched extract promoted the expression of anti-inflammatory cytokines as well as pro-inflammatory cytokines at the degeneration stage. Interestingly, phagocytic activity in the balenine group was significantly higher than that in the control group in vitro. These results suggest that balenine may promote the progress of muscle regeneration by increasing the phagocytic activity of macrophages. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cytokines (日) (読)
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| 3. | (英) Dipeptides (日) (読)
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| 4. | (英) Imidazoles (日) (読)
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| 5. | (英) Macrophages (日) (読)
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| 6. | (英) Mice (日) (読)
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| 7. | (英) Muscle, Skeletal (日) (読)
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| 8. | (英) Phagocytosis (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Marine Drugs (Qingdao hai yang da xue/Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(eISSN: 1660-3397)
| ○ISSN (任意): | □ | 1660-3397
ISSN: 1660-3397
(eISSN: 1660-3397) Title: Marine drugsTitle(ISO): Mar DrugsPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 20
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 313 313
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| ○年月日 (必須): | □ | 西暦 2022年 5月 5日 (令和 4年 5月 5日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/md20050313 (→Scopusで検索)
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| ○PMID (任意): | □ | 35621964 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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