| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない))
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| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Chuluunbat Munkhzaya (日) Munkhzaya Chuluunbat (読) むんくざや ちゅるんばと
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 2. | (英) Matsuda D (日) (読)
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| 3. | 藤田 浩司 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床神経科学]/[徳島大学.病院.診療科.内科.脳神経内科])
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| [継承] |
| 4. | (英) Otomo M (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | 音見 暢一 ([徳島大学.病院.中央診療施設等.放射線部]/[徳島大学.病院.診療科.放射線科.放射線診断科])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Kudo K (日) (読)
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| ○学籍番号 (推奨): |
| [継承] |
| 7. | 原田 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | 和泉 唯信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床神経科学]/[徳島大学.病院.診療科.内科.脳神経内科])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Identification and validation of a gray matter volume network in Alzheimer's disease (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) This study aims to identify and validate a gray matter volume network in patients with Alzheimer's disease (AD). To identify a disease-related network, a principal component analysis-based algorithm, Scaled Subprofile Model, was applied to gray matter volume data derived from structural T1-weighted magnetic resonance imaging of the training sample that consisted of nine patients with AD (women, four; dementia, seven; mild cognitive impairment, two; age, 66.7 ± 8.8 [mean ± SD] years) with positive F-flutemetamol amyloid positron emission tomography and eight age-matched healthy controls obtained on-site. The network expression scores were calculated by topographic profile rating in the validation sample obtained via the Open Access Series of Imaging Studies and comprised 12 patients with AD dementia (women, four; age, 70.0 ± 3.7 years) and 12 age-matched healthy controls. A significant network from the training sample, for which subject expression differed between the groups (permutation test, P = 0.006; sensitivity and specificity, 100%; area under the curve, 1), was identified. This network was represented by the principal components 1, 2, and 3 and showed a relative decrease in the inferior parietal lobule including angular gyrus, inferior temporal gyrus, premotor cortex, amygdala, hippocampus, and precuneus. It significantly differed between the groups with a sensitivity, specificity, and area under the curve of 83%, 91%, and 0.85, respectively, in the validation sample (P = 0.003). An AD-related gray matter volume network that captured relevant regions was identified in amyloid positron emission tomography-positive patients and validated in an independent sample. (日)
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| ○キーワード (推奨): | 1. | (英) Aged (日) (読)
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| 2. | (英) Alzheimer Disease (日) (読)
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| 3. | (英) Amyloid (日) (読)
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| 4. | (英) Brain (日) (読)
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| 5. | (英) Cognitive Dysfunction (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | (英) Gray Matter (日) (読)
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| 8. | (英) Humans (日) (読)
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| 9. | (英) Magnetic Resonance Imaging (日) (読)
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| 10. | (英) Male (日) (読)
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| 11. | (英) Middle Aged (日) (読)
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| 12. | (英) Positron-Emission Tomography (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of the Neurological Sciences (World Federation of Neurology)
(pISSN: 0022-510X, eISSN: 1878-5883)
| ○ISSN (任意): | □ | 1878-5883
ISSN: 0022-510X
(pISSN: 0022-510X, eISSN: 1878-5883) Title: Journal of the neurological sciencesTitle(ISO): J Neurol SciPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 440
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 120344 120344
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 7月 19日 (令和 4年 7月 19日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.jns.2022.120344 (→Scopusで検索)
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| ○PMID (任意): | □ | 35908305 (→Scopusで検索)
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| ○CRID (任意): |
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| ○researchmap (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): | 1. | 和泉 唯信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床神経科学]/[徳島大学.病院.診療科.内科.脳神経内科])
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.jns.2022.120344 (日)
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| 2. | (英) Article.ELocationID: S0022-510X(22)00206-4 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 5. | (英) KeywordList.Keyword: Alzheimer's disease (日)
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| 6. | (英) KeywordList.Keyword: Hippocampus (日)
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| 7. | (英) KeywordList.Keyword: Multivariate analysis (日)
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| 8. | (英) KeywordList.Keyword: Principal component analysis (日)
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| 9. | (英) KeywordList.Keyword: Scaled subprofile model (日)
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| 10. | (英) KeywordList.Keyword: Voxel-based morphometry (日)
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