| ○種別 (必須): | □ | 学術論文 (紀要その他)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Selenge Baasansvren (日) (読)
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| 2. | 山田 眞一郎 ([徳島大学.病院.診療科.外科.消化器・移植外科])
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| 3. | 森根 裕二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 4. | 池本 哲也 ([徳島大学.病院.中央診療施設等.安全管理部]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 5. | 齋藤 裕 ([徳島大学.病院.診療科.外科.消化器・移植外科])
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| 6. | 髙須 千絵 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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| 7. | 寺奥 大貴 ([徳島大学.病院.中央診療施設等.安全管理部])
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| 8. | 島田 光生
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| ○題名 (必須): | □ | (英) Impact of L-type amino acid transporter 3 on the prognosis of hepatocellular carcinoma. (日)
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| ○要約 (任意): | □ | (英) The aim of the present study was to investigate the impact of L-type amino acid transporter 3 (LAT3) expression on the prognosis of hepatocellular carcinoma (HCC). A total of 135 patients who had undergone initial hepatic resection for HCC at Tokushima University Hospital (Tokushima, Japan) were enrolled in the present study. Immunohistochemical analysis of LAT3 and phosphorylated AKT (p-AKT) was performed using resected specimens. Clinicopathological factors, including prognosis, were compared between the LAT3-high and -low expression groups. The results demonstrated that the LAT3-high group showed significantly higher protein induced by vitamin K absence-II levels (P=0.01) compared with the LAT3-low group. The LAT3-high group showed significantly worse prognosis compared with the LAT3-low group regarding cancer-specific survival and disease-free survival (P<0.05). Multivariate analysis revealed that high LAT3 expression and multiple tumors were independent prognostic factors for cancer-specific survival. Furthermore, the rate of p-AKT-positive cases was higher in the LAT3-high group than in the LAT3-low group. Overall, these findings suggested that LAT3 expression was associated with poor prognosis of HCC and high p-AKT expression. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Oncology Letters (Spandidos Publications)
(pISSN: 1792-1074, eISSN: 1792-1082)
| ○ISSN (任意): | □ | 1792-1082
ISSN: 1792-1074
(pISSN: 1792-1074, eISSN: 1792-1082) Title: Oncology lettersTitle(ISO): Oncol LettPublisher: Spandidos Publications (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 24
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 418 418
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| ○年月日 (必須): | □ | 西暦 2022年 9月 30日 (令和 4年 9月 30日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3892/ol.2022.13538 (→Scopusで検索)
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| ○PMID (任意): | □ | 36245821 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 418 (日)
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| 2. | (英) Article.ELocationID: 10.3892/ol.2022.13538 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: HCC (日)
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| 5. | (英) KeywordList.Keyword: LAT3 (日)
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| 6. | (英) KeywordList.Keyword: amino acid (日)
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| 7. | (英) KeywordList.Keyword: leucine (日)
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| 8. | (英) KeywordList.Keyword: p-AKT (日)
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| 9. | (英) CoiStatement: MS declares receiving an unrestricted research grant from Bayer Yakuhin, Co. Ltd., Japan. All other authors declare that they have no competing interests. (日)
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