| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 田良島 典子 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.統合医薬創製科学系.生物有機化学])
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| 2. | (英) Murai Akiho (日) 村井 あきほ (読) むらい あきほ
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| ○学籍番号 (推奨): | □ | ****
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| 3. | 南川 典昭 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.統合医薬創製科学系.生物有機化学])
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| ○題名 (必須): | □ | (英) Rewriting the Central Dogma with Synthetic Genetic Polymers (日)
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| ○要約 (任意): | □ | (英) DNA and RNA are ubiquitous molecules responsible for storage and transmission of genetic information and together comprise the central dogma of molecular biology. However, the recent emergence of synthetic genetic polymers is providing an opportunity to challenge the fundamental principles of life. Herein, we describe the ongoing attempts to rewrite the central dogma with 4'-thioDNA and 4'-thioRNA, which feature a sulfur instead of an oxygen atom in the furanose ring moiety. Using reconstituted Escherichia coli gene expression machinery, studies have shown that the genetic information conserved in 4'-thioDNA can be transcribed to 4'-thioRNA and eventually translated into protein, mirroring the processes that occur in nature. Such studies underscore the feasibility of controlling life by substances other than DNA and RNA. (日)
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| ○キーワード (推奨): | 1. | (英) DNA (日) (読)
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| 2. | (英) Polymers (日) (読)
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| 3. | (英) RNA (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Chemical & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0009-2363, eISSN: 1347-5223)
| ○ISSN (任意): | □ | 1347-5223
ISSN: 0009-2363
(pISSN: 0009-2363, eISSN: 1347-5223) Title: Chemical & pharmaceutical bulletinTitle(ISO): Chem Pharm Bull (Tokyo)Supplier: 公益社団法人日本薬学会Publisher: Pharmaceutical Society of Japan (NLM Catalog)
(CiNii NCID)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 70
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 310 315
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 5月 1日 (令和 4年 5月 1日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1248/cpb.c21-00960 (→Scopusで検索)
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| ○PMID (任意): | □ | 35491185 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1248/cpb.c21-00960 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: 4'-thioDNA (日)
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| 4. | (英) KeywordList.Keyword: 4'-thioRNA (日)
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| 5. | (英) KeywordList.Keyword: 4'-thionucleotide (日)
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| 6. | (英) KeywordList.Keyword: central dogma (日)
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| 7. | (英) KeywordList.Keyword: oligonucleotide (日)
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| 8. | (英) KeywordList.Keyword: synthetic biology (日)
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