| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学 (2015年4月1日〜)
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| ○著者 (必須): | 1. | 佐藤 真美 ([徳島大学.病院.診療科.歯科口腔外科.口腔内科]/[徳島大学.病院.先端歯科医療開発研究プロジェクト]/->個人[福場 真美])
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 新垣 理恵子
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| 3. | (英) Tawara Hiroaki (日) 俵 宏彰 (読) たわら ひろあき
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| ○学籍番号 (推奨): | □ | ****
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| 4. | (英) Nagao Ruka (日) 永尾 瑠佳 (読) ながお るか
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| ○学籍番号 (推奨): | □ | ****
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| 5. | (英) Tanaka Hidetaka (日) 田中 秀卓 (読) たなか ひでたか
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| ○学籍番号 (推奨): | □ | ****
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| 6. | (英) Tamura Kai (日) 田村 海 (読) たむら かい
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| ○学籍番号 (推奨): | □ | ****
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| 7. | (英) Kawahito Yuki (日) 川人 祐樹 (読) かわひと ゆうき
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| ○学籍番号 (推奨): | □ | ****
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| 8. | 牛尾 綾
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| 9. | 常松 貴明 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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| 10. | 石丸 直澄
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| ○題名 (必須): | □ | (英) Disturbed natural killer cell homeostasis in the salivary gland enhances autoimmune pathology via IFN-γ in a mouse model of primary Sjogren's syndrome. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1, ILC2, lymphoid tissue-inducer (LTi) cells, and ILC3 cell, play a key role in various immune responses. Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by chronic inflammation of exocrine glands, such as the lacrimal and salivary glands (SGs). The role of NK cells among ILCs in the pathogenesis of pSS is still unclear. In this study, the characteristics and subsets of NK cells in the salivary gland (SG) tissue were analyzed using a murine model of pSS. Multiple phenotypes and cytotoxic signature of the SG NK cells in control and pSS model mice were evaluated by flow cytometric analysis. Intracellular expression of interferon-γ (IFN-γ) among T cells and NK cells from the SG tissues was compared by experiments. In addition, pathological analysis was performed using anti-asialo-GM1 (ASGM1) antibody (Ab)-injected pSS model mice. The number of conventional NK (cNK) cells in the SG of pSS model mice significantly increased compared with that in control mice at 6 weeks of age. The production level of IFN-γ was significantly higher in SG NK cells than in SG T cells. The depletion of NK cells by ASGM1 Ab altered the ratio of tissue resident NK (rNK) cells to cNK cells, which inhibited the injury to SG cells with the recovery of saliva secretion in pSS model mice. The results indicate that SG cNK cells may enhance the autoreactive response in the target organ by upregulating of IFN-γ, whereas SG rNK cells protect target cells against T cell cytotoxicity. Therefore, the activation process and multiple functions of NK cells in the target organ could be helpful to develop potential markers for determining autoimmune disease activity and target molecules for incurable immune disorders. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Frontiers in Medicine (Frontiers Media S.A.)
(eISSN: 2296-858X)
| ○ISSN (任意): | □ | 2296-858X
ISSN: 2296-858X
(eISSN: 2296-858X) Title: Frontiers in medicineTitle(ISO): Front Med (Lausanne)Publisher: Frontiers Media SA (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 9
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 1036787 1036787
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 10月 26日 (令和 4年 10月 26日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3389/fmed.2022.1036787 (→Scopusで検索)
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| ○PMID (任意): | □ | 36388880 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 1036787 (日)
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| 2. | (英) Article.ELocationID: 10.3389/fmed.2022.1036787 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: IFN-γ (日)
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| 5. | (英) KeywordList.Keyword: NK cell (日)
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| 6. | (英) KeywordList.Keyword: Sjögren's syndrome (日)
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| 7. | (英) KeywordList.Keyword: T cell (日)
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| 8. | (英) KeywordList.Keyword: autoimmunity (日)
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| 9. | (英) CoiStatement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (日)
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