| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 曽我部 正弘 ([徳島大学.キャンパスライフ健康支援センター])
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| 2. | 岡久 稔也 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域総合医療学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 3. | 香川 美和子
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| ○学籍番号 (推奨): | □ | ****
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| 4. | 上田 浩之
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| ○学籍番号 (推奨): | □ | ****
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| 5. | 影本 開三 ([徳島大学.病院.中央診療施設等.がん診療連携センター])
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| ○学籍番号 (推奨): | □ | ****
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| 6. | 田中 宏典 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.消化器内科])
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| ○学籍番号 (推奨): | □ | ****
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| 7. | 喜田 慶史 ([徳島大学.大学院医歯薬学研究部.医学域.先端臨床医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○学籍番号 (推奨): | □ | ****
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| 8. | 友成 哲
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| ○学籍番号 (推奨): | □ | ****
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| 9. | 谷口 達哉
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| ○学籍番号 (推奨): | □ | ****
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| 10. | 岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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| 11. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 12. | 佐藤 康史 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域消化器・総合内科学])
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| 13. | (英) Nakasono Masahiko (日) (読)
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| 14. | 高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○題名 (必須): | □ | (英) Influence of alcohol on newly developed metabolic dysfunction-associated fatty liver disease in both sexes: A longitudinal study. (日)
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| ○要約 (任意): | □ | (英) The influence of changes in alcohol consumption on newly developed metabolic dysfunction-associated fatty liver disease (MAFLD) is unclear. We investigated the influence of alcohol consumption on newly developed MAFLD in both sexes. This observational cohort study included 4071 patients who underwent more than two health check-ups between 2015 and 2020 over an interval of more than a year. Generalised estimating equations were used for analyses. At baseline, the rates of drinking and MAFLD between men and women were 72.5% versus 41.7% and 42.2% versus 22.1%, respectively. At the most recent stage, the rates of an increase in alcohol consumption for men and women were 13.3% and 8.7%, respectively, and 311/1192 (26.1%) men and 155/1566 (9.9%) women had newly developed MAFLD. The odds ratio (OR) for drinking in patients with newly developed MAFLD was 0.863 (men) (95% confidence interval [CI], 0.676-1.102, p = 0.237) and 1.041 (women) (95% CI, 0.753-1.439, p = 0.808); the OR for women who drank 140-279.9 g/week was 2.135 (95% CI, 1.158-3.939, p < 0.05) and that for all drinking categories among women was >1. Several non-invasive fibrosis scores were significantly associated with the quantity of alcohol consumption in patients with newly developed MAFLD (p < 0.005). Alcohol consumption had no significant protective effect against newly developed MAFLD in both sexes, regardless of quantity. Conversely, alcohol consumption ≥140 g/week was a risk factor for newly developed MAFLD in women. The development of liver fibrosis with increased alcohol intake should be considered in patients with MAFLD. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Clinical Nutrition (European Society of Parenteral and Enteral Nutrition/European Society for Clinical Nutrition and Metabolism)
(pISSN: 0261-5614, eISSN: 1532-1983)
| ○ISSN (任意): | □ | 1532-1983
ISSN: 0261-5614
(pISSN: 0261-5614, eISSN: 1532-1983) Title: Clinical nutrition (Edinburgh, Scotland)Title(ISO): Clin NutrPublisher: Churchill Livingstone (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 42
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 810 816
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2023年 3月 31日 (令和 5年 3月 31日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.clnu.2023.03.020 (→Scopusで検索)
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| ○PMID (任意): | □ | 37043935 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.clnu.2023.03.020 (日)
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| 2. | (英) Article.ELocationID: S0261-5614(23)00101-2 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Ages (日)
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| 5. | (英) KeywordList.Keyword: Alcohol drinking (日)
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| 6. | (英) KeywordList.Keyword: Liver diseases (日)
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| 7. | (英) KeywordList.Keyword: Onset (日)
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| 8. | (英) KeywordList.Keyword: Sex (日)
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| 9. | (英) CoiStatement: Conflicts of interest The authors declare that there are no conflicts of interest. (日)
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