| ○種別 (必須): | □ | 学術論文 (紀要その他)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 髙須 千絵 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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| 2. | 西 正暁 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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| 3. | 吉川 幸造
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| 4. | 徳永 卓哉 ([徳島大学.病院.中央診療施設等.地域外科診療部])
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| 5. | 中尾 寿宏
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| 6. | 柏原 秀也 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 7. | 和田 佑馬 ([徳島大学.病院.診療科.外科.消化器・移植外科])
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| 8. | 良元 俊昭 ([徳島大学.病院.栄養部])
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| 9. | (英) Okikawa Shohei (日) (読)
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| 10. | (英) Yamashita Shoko (日) (読)
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| 11. | 島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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| ○題名 (必須): | □ | (英) Role of IDO expression in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy. (日)
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| ○要約 (任意): | □ | (英) The role of the immune system in locally advanced rectal cancer (LARC) following preoperative chemoradiotherapy (CRT) has been widely investigated in recent years. This study examined the prognostic significance of indoleamine-pyrrole 2,3-dioxygenase (IDO) expression in patients with LARC who received preoperative CRT. Ninety patients with LARC who underwent preoperative CRT and curative resection were enrolled. IDO and programmed death-ligand 1 (PD-L1) expression was evaluated by immunohistochemistry. Clinicopathological factors did not significantly differ between patients with positive or negative IDO expression, excluding the correlation of positive IDO expression with better tumor differentiation (p = 0.02). IDO expression was not associated with pathological response (p = 0.44), but it was associated with PD-L1 expression. The 5-year overall survival (OS) rate was significantly worse in the IDO-positive group than in the IDO-negative group (64.8% vs. 85.4%, p = 0.02). Univariate analysis identified IDO and PD-L1 expression (p = 0.02), surgical procedure (p = 0.01), final pathological stage (p = 0.003), lymph node metastasis (p < 0.001), and lymphatic invasion (p = 0.002) as significant prognostic factors for OS. Multivariate analysis revealed that IDO expression (HR: 7.10, p = 0.0006), surgical procedure (HR: 5.03, p = 0.01), lymph node metastasis (HR: 2.37, p = 0.04) and lymphatic invasion (HR: 4.97, p = 0.01) were independent prognostic indicators. Disease-free survival was not correlated with IDO or PD-L1 expression. IDO expression in patients with LARC who received preoperative CRT could be a potential prognostic indicator. IDO expression could be a useful marker for specifying individual treatment strategies in LARC. (日)
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| ○キーワード (推奨): | 1. | (英) Humans (日) (読)
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| 2. | (英) B7-H1 Antigen (日) (読)
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| 3. | (英) Chemoradiotherapy (日) (読)
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| 4. | (英) Lymphatic Metastasis (日) (読)
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| 5. | (英) Neoadjuvant Therapy (日) (読)
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| 6. | (英) Prognosis (日) (読)
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| 7. | (英) Rectal Neoplasms (日) (読)
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| 8. | (英) Indoleamine-Pyrrole 2,3,-Dioxygenase (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | BMC Cancer ([BioMed Central Ltd.])
(eISSN: 1471-2407)
| ○ISSN (任意): | □ | 1471-2407
ISSN: 1471-2407
(eISSN: 1471-2407) Title: BMC cancerTitle(ISO): BMC CancerPublisher: BioMed Central (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 22
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 1263 1263
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 12月 5日 (令和 4年 12月 5日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1186/s12885-022-10357-1 (→Scopusで検索)
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| ○PMID (任意): | □ | 36471264 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 1263 (日)
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| 2. | (英) Article.ELocationID: 10.1186/s12885-022-10357-1 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: CRT (日)
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| 5. | (英) KeywordList.Keyword: Immune escape (日)
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| 6. | (英) KeywordList.Keyword: Neoadjuvant (日)
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| 7. | (英) KeywordList.Keyword: PD-L1 (日)
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| 8. | (英) CoiStatement: The authors declare that they have no competing interests. (日)
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