| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 2. | 細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.再生歯科治療学])
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| 3. | (英) Shimoyama Masahiro (日) 下山 真弘 (読) しもやま まさひろ
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| ○学籍番号 (推奨): | □ | ****
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| 4. | (英) Fujii Ayumi (日) 藤井 亜祐美 (読) ふじい あゆみ
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| ○学籍番号 (推奨): | □ | ****
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| 5. | (英) Sato Juri (日) 佐藤 朱里 (読) さとう じゅり
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| ○学籍番号 (推奨): | □ | ****
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| 6. | (英) Kadena Kimitake (日) 嘉手納 公威 (読) かでな きみたけ
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| ○学籍番号 (推奨): | □ | ****
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| 7. | 尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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| 8. | 保坂 啓一 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.再生歯科治療学])
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| ○題名 (必須): | □ | (英) The Anti-Inflammatory Effects of Iberin on TNF-α-Stimulated Human Oral Epithelial Cells: In Vitro Research. (日)
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| ○要約 (任意): | □ | (英) Iberin is a bioactive chemical found in cruciferous plants that has been demonstrated to have anticancer properties. However, there have been no reports on its effects on periodontal resident cells, and many questions remain unanswered. The aim of this study was to examine whether iberin had anti-inflammatory effects on human oral epithelial cells, including influences on signal transduction pathway activation in TNF-α-στιμυλατεd χελλσ. Iberin inhibited the production of interleukin (IL)-6 and C-X-C motif chemokine ligand 10 (CXCL10), as well as the expression of vascular cell adhesion molecule (VCAM)-1, inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2 in tumor necrosis factor (TNF)-α-stimulated TR146 cells, a human oral epithelial cell line. Moreover, iberin administration increased the expression of antioxidant signaling pathways, such as Heme Oxygenase (HO)-1 and NAD(P)H quinone dehydrogenase 1 (NQO1). Furthermore, we found that iberin could inhibit the activation of the nuclear factor (NF)-κB, signal transducer and activator of transcription (STAT)3, and p70S6 kinase (p70S6K)-S6 ribosomal protein (S6) pathways in TNF-α-stimulated TR146 cells. In conclusion, iberin reduced inflammatory mediator expression in human oral epithelial cells by preventing the activation of particular signal transduction pathways. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Biomedicines (MDPI AG)
(eISSN: 2227-9059)
| ○ISSN (任意): | □ | 2227-9059
ISSN: 2227-9059
(eISSN: 2227-9059) Title: BiomedicinesTitle(ISO): BiomedicinesPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 10
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| ○号 (必須): | □ | 12
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| ○頁 (必須): |
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| ○年月日 (必須): | □ | 西暦 2022年 12月 6日 (令和 4年 12月 6日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/biomedicines10123155 (→Scopusで検索)
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| ○PMID (任意): | □ | 36551911 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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