| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Zhang Yuehui (日) ZHANG YUEHUI (読) ちょう ゆえふぃ
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 細木 眞紀 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.顎機能咬合再建学])
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| 3. | 大島 正充 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.顎機能咬合再建学])
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| 4. | 田島 登誉子
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| 5. | 宮城 麻友
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| 6. | (英) Raman S (日) RAMAN SWARNA LAKSHMI (読) らまん すわるな らくしゅみ
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| ○学籍番号 (推奨): | □ | ****
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| 7. | (英) Raju R (日) RESMI RAJU (読) れすみ らじゅ
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| ○学籍番号 (推奨): | □ | ****
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| 8. | 松香 芳三 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.顎機能咬合再建学])
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| ○題名 (必須): | □ | (英) Identification of microRNA signatures in peripheral blood of young women as potential biomarkers for metal allergy (日)
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| ○要約 (任意): | □ | (英) MicroRNA (miRNA) is a short (19-24 nucleotide) endogenous non-protein RNA that exists in the body and controls the translation process from genes to proteins. It has become useful as a diagnostic tool and a potential treatment target in cancer research. To explore the function of miRNA in contact dermatitis, female participants with a positive metal allergy diagnosis ( = 3) were enrolled along with additional female participants with no medical history of metal allergy ( = 3). A patch test was performed on each participant. Peripheral blood was collected from all the participants before the patch test and at days 3 and 7 after starting the patch test. After total RNA was obtained from peripheral blood leukocytes and cDNA was generated, microarray analysis was performed to analyze the large-scale circulating miRNA profile. Real-time polymerase chain reaction (RT-PCR) was then used to clarify the overall target miRNA expression. Downregulation of hsa-let-7d-5p, hsa-miR-24-3p, hsa-miR-23b-3p, hsa-miR-26b-5p, and hsa-miR-150-5p was found on day 7. Certain miRNAs were confirmed using RT-PCR. These peripheral blood miRNAs could be diagnostic biomarkers for metal allergies. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Biomedicines (MDPI AG)
(eISSN: 2227-9059)
| ○ISSN (任意): | □ | 2227-9059
ISSN: 2227-9059
(eISSN: 2227-9059) Title: BiomedicinesTitle(ISO): BiomedicinesPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 11
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 277 277
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| ○年月日 (必須): | □ | 西暦 2023年 1月 19日 (令和 5年 1月 19日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/biomedicines11020277 (→Scopusで検索)
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| ○PMID (任意): | □ | 36830814 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 277 (日)
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| 2. | (英) Article.ELocationID: 10.3390/biomedicines11020277 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: allergic contact dermatitis (日)
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| 5. | (英) KeywordList.Keyword: biomarker (日)
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| 6. | (英) KeywordList.Keyword: metal allergy (日)
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| 7. | (英) KeywordList.Keyword: microRNA (日)
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| 8. | (英) KeywordList.Keyword: peripheral blood (日)
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| 9. | (英) CoiStatement: The authors declare no conflict of interest. (日)
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