| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Fukutomi Mayu (日) 福富 茉由 (読) ふくとみ まゆ
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| ○学籍番号 (推奨): | □ | ****
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| 2. | (英) Uedono Chiharu (日) 上殿 千晴 (読) うえどの ちはる
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| ○学籍番号 (推奨): | □ | ****
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| 3. | (英) Fujii Aki (日) 藤井 亜紀 (読) ふじい あき
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| ○学籍番号 (推奨): | □ | ****
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| 4. | 佐藤 陽一 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品情報学])
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| ○題名 (必須): | □ | (英) Lrriq1 is an essential factor for fertility by suppressing apoptosis. (日)
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| ○要約 (任意): | □ | (英) Leucine-rich repeats and IQ motif containing 1 (LRRIQ1) gene is reportedly associated with plasma inhibin B levels. However, the function of LRRIQ1 remains unknown. In this study, we generated Lrriq1 knockout mice (Lrriq1 mice) and examined the effects of LRRIQ1 on inhibin B and fertility. Lrriq1 mice were generated using CRISPR/Cas9 genome editing technology. The expression of Inhibin B was examined by Western blotting using a protein extracted from the testis of a 3-month-old male mouse. Mating experiments were conducted using 7-week-old Lrriq1 mice and wild-type (WT) mice to examine fertility. Sperm concentration and sperm motility were measured using 3-month-old male mice. Expression analysis of inhibin B revealed that Lrriq1 mice exhibited reduced mRNA and protein levels of inhibin alpha (Inha), which constitutes the α subunit. In the mating experiment, the litter size of Lrriq1 male mice was 4.3 ± 2.9, which was significantly lower than that of WT male mice (8.3 ± 1.3) (p < 0.001). No difference in sperm count was observed between Lrriq1 and WT male mice; however, sperm motility (%) was significantly reduced in Lrriq1 mice (48.4 ± 4.9) when compared with WT mice (70.2 ± 4.7) (p < 0.001). Based on TUNEL staining, the testes and epididymal sperm of Lrriq1 mice showed high numbers of apoptosis-positive cells. Lrriq1 knockout reduced sperm motility and litter size by inducing apoptosis of testicular germ cells and epididymal sperm. (日)
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| ○キーワード (推奨): | 1. | (英) Male (日) (読)
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| 2. | (英) Mice (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | (英) Sperm Motility (日) (読)
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| 5. | (英) Semen (日) (読)
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| 6. | (英) Fertility (日) (読)
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| 7. | (英) Sperm Count (日) (読)
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| 8. | (英) Testis (日) (読)
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| 9. | (英) Spermatozoa (日) (読)
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| 10. | (英) Mice, Knockout (日) (読)
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| 11. | (英) Apoptosis (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Assisted Reproduction and Genetics (International Working Group on Preimplantation Genetics)
(pISSN: 1058-0468, eISSN: 1573-7330)
| ○ISSN (任意): | □ | 1573-7330
ISSN: 1058-0468
(pISSN: 1058-0468, eISSN: 1573-7330) Title: Journal of assisted reproduction and geneticsTitle(ISO): J Assist Reprod GenetSupplier: Kluwer OnlinePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 39
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| ○号 (必須): | □ | 11
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| ○頁 (必須): | □ | 2647 2657
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 11月 初日 (令和 4年 11月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s10815-022-02623-9 (→Scopusで検索)
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| ○PMID (任意): | □ | 36129630 (→Scopusで検索)
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| ○指導教員 (推奨): | 1. | 佐藤 陽一 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品情報学])
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s10815-022-02623-9 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Apoptosis (日)
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| 4. | (英) KeywordList.Keyword: Fertility (日)
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| 5. | (英) KeywordList.Keyword: Inhibin B (日)
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| 6. | (英) KeywordList.Keyword: Lrriq1 (日)
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| 7. | (英) KeywordList.Keyword: Sperm motility (日)
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| 8. | (英) CoiStatement: The authors declare no conflict of interest. (日)
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