| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Shimoyama Masahiro (日) 下山 真弘 (読) しもやま まさひろ
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 3. | 細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.⻭科保存学])
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| 4. | 尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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| 5. | 保坂 啓一 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.⻭科保存学]/[徳島大学.ポストLEDフォトニクス研究所])
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| ○題名 (必須): | □ | (英) 6-(Methylsulfinyl) Hexyl Isothiocyanate Inhibits IL-6 and CXCL10 Production in TNF-α-Stimulated Human Oral Epithelial Cells. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) 6-(Methylsulfinyl) hexyl isothiocyanate (6-MSITC) is a bioactive substance found in wasabi (Wasabia japonica) and has been reported to have some bioactive effects including anticancer and antioxidant effects. However, there are no reports on its effects on periodontal resident cells, and many points remain unclear. In this study, we aimed to investigate whether 6-MSITC exerts anti-inflammatory effects on human oral epithelial cells, including effects on signal transduction pathway activation. 6-MSITC inhibited interleukin (IL)-6 and C-X-C motif chemokine ligand 10 (CXCL10) production in TNF-α-stimulated TR146 cells, which are a human oral epithelial cell line. Moreover, we found that 6-MSITC could suppress signal transducer and activator of transcription (STAT)3, nuclear factor (NF)-κB, and p70S6 kinase (p70S6K)-S6 ribosomal protein (S6) pathways activation in TNF-α-stimulated TR146 cells. Furthermore, STAT3 and NF-κB inhibitors could suppress IL-6 and CXCL10 production in TNF-α-treated TR146 cells. In summary, 6-MSITC could decrease IL-6 and CXCL10 production in human oral epithelial cell by inhibiting STAT3 and NF-κB activation. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Current Issues in Molecular Biology (Caister Academic Press)
(pISSN: 1467-3037, eISSN: 1467-3045)
| ○ISSN (任意): | □ | 1467-3045
ISSN: 1467-3037
(pISSN: 1467-3037, eISSN: 1467-3045) Title: Current issues in molecular biologyTitle(ISO): Curr Issues Mol BiolPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
(CrossRef)
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| ○巻 (必須): | □ | 44
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 2915 2922
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 6月 29日 (令和 4年 6月 29日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/cimb44070201 (→Scopusで検索)
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| ○PMID (任意): | □ | 35877425 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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