| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Aurpita Shaha (日) Aurpita Shaha (読) おるぴた しゃは
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 2. | (英) Rezwanul Islam (日) Rezwanul Islam (読) れずわぬる いすらむ
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 3. | 田中 直伸 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.生薬学])
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| 4. | 柏田 良樹
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| 5. | 福井 裕行
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| 6. | 武田 憲昭
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| 7. | 北村 嘉章 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.耳鼻咽喉科・頭頸部外科学]/[徳島大学.病院.診療科.感覚·皮膚·運動機能科.耳鼻咽喉科・頭頸部外科])
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| 8. | 水口 博之
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| ○題名 (必須): | □ | (英) Betuletol, a propolis component, suppresses IL-33 gene expression and effective against eosinophilia (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Propolis, a resinous substance produced by honeybees, has been used in folk medicine since ancient times due to its many biological benefits such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory effects. Propolis contains flavonoids, terpenoids, aromatic aldehydes, and alcohols, which vary with different climate and environmental conditions. In our study, we examined the antiallergic activity of Brazilian green propolis (BGP) and isolated the active compound that can suppress an allergy-sensitive gene, IL-33, expression and eosinophilia. Ethanolic extract of BGP freeze-dried powder was fractionated with several solvent systems, and the active fractions were collected based on activity measurement. The single active compound was found by thin-layer chromatography. Using column chromatography and NMR, the active compound was isolated and identified as 3,5,7-trihydroxy-6,4'-dimethoxyflavone, also known as betuletol. Further, the antiallergic activity of that has been examined in PMA-induced up-regulation of IL-33 gene expression in Swiss 3T3 cells. Our data showed the IL-33 gene suppression both by BGP and the isolated active compound, betuletol. We also found that betuletol suppressed ERK phosphorylation, suggesting it could be effective in suppressing IL-33 mediated eosinophilic chronic inflammation and will provide new insights to develop potent therapeutics against allergic inflammations. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Anti-Allergic Agents (日) (読)
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| 3. | (英) Eosinophilia (日) (読)
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| 4. | (英) Gene Expression (日) (読)
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| 5. | (英) Inflammation (日) (読)
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| 6. | (英) Interleukin-33 (日) (読)
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| 7. | (英) Mice (日) (読)
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| 8. | (英) Propolis (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Molecules (Molecular Diversity Preservation International)
(pISSN: 1433-1373, eISSN: 1420-3049)
| ○ISSN (任意): | □ | 1420-3049
ISSN: 1420-3049
(pISSN: 1433-1373, eISSN: 1420-3049) Title: Molecules (Basel, Switzerland)Title(ISO): MoleculesSupplier: Springer Online Journal ArchivePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
(CrossRef)
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| ○巻 (必須): | □ | 27
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| ○号 (必須): | □ | 17
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| ○頁 (必須): | □ | 5459 5459
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| ○年月日 (必須): | □ | 西暦 2022年 8月 25日 (令和 4年 8月 25日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/molecules27175459 (→Scopusで検索)
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| ○PMID (任意): | □ | 36080225 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-85137579924
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 5459 (日)
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| 2. | (英) Article.ELocationID: 10.3390/molecules27175459 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: IL-33 (日)
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| 5. | (英) KeywordList.Keyword: allergic rhinitis (日)
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| 6. | (英) KeywordList.Keyword: betuletol (日)
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| 7. | (英) KeywordList.Keyword: eosinophilia (日)
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| 8. | (英) KeywordList.Keyword: propolis (日)
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| 9. | (英) CoiStatement: The authors declare no conflict of interest. (日)
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