| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Sumitomo Ryota (日) (読)
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| 2. | (英) Huang Cheng-long (日) (読)
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| 3. | 安藤 英紀 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.薬物動態制御学])
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| 4. | 石田 竜弘 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.薬物動態制御学]/[徳島大学.大学院医歯薬学研究部.薬学域.連携研究部門(薬学域).寄附講座系(薬学域).がん細胞と代謝学]/[徳島大学.大学産業院])
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| 5. | (英) Cho Hiroyuki (日) (読)
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| 6. | (英) Date Hiroshi (日) (読)
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| ○題名 (必須): | □ | (英) Wnt2b and Wnt5a expressions are highly associated with M2 TAMs in non-small-cell lung cancer (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Tumor-associated macrophages (TAMs), particularly M2 macrophages, promote tumor progression, while genes encode a family of multi-functional glycoproteins that serve an important role in tumorigenesis. Immunohistochemical studies were performed to evaluate Wnt2b and Wnt5a expression in tumor and stromal cells in M2 and M1 TAMs and Ki-67 proliferation index in 160 consecutive patients with resected non-small cell lung cancer (NSCLC). Overall, 52 tumors (32.5%) were classified as tumoral Wnt2b-high (Wnt2b-positive tumor cells >30%) and 95 (59.4%) as stromal Wnt2b-high (Wnt2b-positive stromal cells >30%), while 75 (46.9%) were classified as tumoral Wnt5a-high (Wnt5a-positive tumor cells >30%) and 63 (39.4%) as stromal Wnt5a-high (Wnt5a-positive stromal cells >28%). The density of M2 TAMs was significantly higher in the tumoral (P=0.0024) and stromal Wnt2b-high groups (P=0.0054). The density of M2 TAMs was also significantly higher in the tumoral (P=0.0005) and stromal Wnt5a-high groups (P=0.0486). By contrast, no difference in stromal or islet M1 TAM density was observed in relation to tumoral or stromal Wnt2b or Wnt5a status. Furthermore, Ki-67 proliferation index was significantly higher in the tumoral (P=0.0121) and stromal Wnt2b-high (P=0.0019) and tumoral Wnt5a-high (P=0.0088) groups. Overall survival rate was significantly lower in the Wnt2b-high (P=0.0437), Wnt5a-high (P=0.0106) and M2 TAM-high (P=0.0060) groups. Wnt2b and Wnt5a expression in tumor and stromal cells may induce M2 TAMs to produce more aggressive behavior during tumor progression in NSCLC. (日)
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| ○キーワード (推奨): | 1. | (英) Carcinoma, Non-Small-Cell Lung (日) (読)
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| 2. | (英) Glycoproteins (日) (読)
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| 3. | (英) Humans (日) (読)
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| 4. | (英) Immunohistochemistry (日) (読)
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| 5. | (英) Ki-67 Antigen (日) (読)
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| 6. | (英) Lung Neoplasms (日) (読)
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| 7. | (英) Tumor-Associated Macrophages (日) (読)
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| 8. | (英) Wnt Proteins (日) (読)
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| 9. | (英) Wnt-5a Protein (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Oncology Reports (Ethnikon Hidryma Ereunōn (Greece))
(pISSN: 1021-335X, eISSN: 1791-2431)
| ○ISSN (任意): | □ | 1791-2431
ISSN: 1021-335X
(pISSN: 1021-335X, eISSN: 1791-2431) Title: Oncology reportsTitle(ISO): Oncol RepPublisher: Spandidos Publications (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 48
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 189 189
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 4月 20日 (令和 4年 4月 20日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2139/ssrn.4088768 (→Scopusで検索)
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| ○PMID (任意): | □ | 36102318 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 189 (日)
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| 2. | (英) Article.ELocationID: 10.3892/or.2022.8404 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: CD163 (日)
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| 5. | (英) KeywordList.Keyword: Ki-67 (日)
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| 6. | (英) KeywordList.Keyword: Wnt2b (日)
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| 7. | (英) KeywordList.Keyword: Wnt5a (日)
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| 8. | (英) KeywordList.Keyword: lung cancer (日)
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| 9. | (英) KeywordList.Keyword: macrophage (日)
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| 10. | (英) CoiStatement: The authors declare that they have no competing interests. (日)
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