| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kurosawa Mie (日) (読)
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| 2. | (英) Shikama Yosuke (日) (読)
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| 3. | (英) Furukawa Masae (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | 新垣 理恵子
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| 5. | 石丸 直澄
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| 6. | (英) Matsushita Kenji (日) (読)
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| ○題名 (必須): | □ | (英) Chemokines Up-Regulated in Epithelial Cells Control Senescence-Associated T Cell Accumulation in Salivary Glands of Aged and Sjögren's Syndrome Model Mice. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Immunosenescence is characterized by age-associated changes in immunological functions. Although age- and autoimmune-related sialadenitis cause dry mouth (xerostomia), the roles of immunosenescence and cellular senescence in the pathogenesis of sialadenitis remain unknown. We demonstrated that acquired immune cells rather than innate immune cells infiltrated the salivary glands (SG) of aged mice. An analysis of isolated epithelial cells from SG revealed that the expression levels of the chemokine CXCL13 were elevated in aged mice. Senescence-associated T cells (SA-Ts), which secrete large amounts of atypical pro-inflammatory cytokines, are involved in the pathogenesis of metabolic disorders and autoimmune diseases. The present results showed that SA-Ts and B cells, which express the CXCL13 receptor CXCR5, accumulated in the SG of aged mice, particularly females. CD4 T cells derived from aged mice exhibited stronger in vitro migratory activity toward CXCL13 than those from young mice. In a mouse model of Sjögren's syndrome (SS), SA-Ts also accumulated in SG, presumably via CXCL12-CXCR4 signaling. Collectively, the present results indicate that SA-Ts accumulate in SG, contribute to the pathogenesis of age- and SS-related sialadenitis by up-regulating chemokines in epithelial cells, and have potential as therapeutic targets for the treatment of xerostomia caused by these types of sialadenitis. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Autoimmune Diseases (日) (読)
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| 3. | (英) B-Lymphocytes (日) (読)
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| 4. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 5. | (英) Cell Movement (日) (読)
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| 6. | (英) Cellular Senescence (日) (読)
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| 7. | (英) Chemokine CXCL13 (日) (読)
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| 8. | (英) Chemokines (日) (読)
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| 9. | (英) Disease Models, Animal (日) (読)
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| 10. | (英) Epithelial Cells (日) (読)
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| 11. | 女性 (female)
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| 12. | (英) Gene Expression Regulation (日) (読)
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| 13. | 男性 (male)
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| 14. | (英) Mice (日) (読)
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| 15. | (英) Mice, Inbred C57BL (日) (読)
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| 16. | (英) Receptors, CXCR5 (日) (読)
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| 17. | 唾液腺 (salivary glands/->キーワード[唾液腺])
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| 18. | (英) Sialadenitis (日) (読)
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| 19. | シェーグレン症候群 (Sjögren's syndrome)
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| 20. | Tリンパ球 (T lymphocytes)
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| 21. | (英) Xerostomia (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | International Journal of Molecular Sciences (Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(pISSN: 1661-6596, eISSN: 1422-0067)
| ○ISSN (任意): | □ | 1422-0067
ISSN: 1661-6596
(pISSN: 1661-6596, eISSN: 1422-0067) Title: International journal of molecular sciencesTitle(ISO): Int J Mol SciPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 22
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 2302 2302
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2021年 3月 25日 (令和 3年 3月 25日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/ijms22052302 (→Scopusで検索)
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| ○PMID (任意): | □ | 33669065 (→Scopusで検索)
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| ○CRID (任意): |
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 2302 (日)
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| 2. | (英) Article.ELocationID: 10.3390/ijms22052302 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: cellular senescence (日)
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| 5. | (英) KeywordList.Keyword: chemokines (日)
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| 6. | (英) KeywordList.Keyword: immunosenescence (日)
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| 7. | (英) KeywordList.Keyword: sialadenitis (日)
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| 8. | (英) KeywordList.Keyword: xerostomia (日)
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