| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
| [継承] |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Sakaki Yuki (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | 漆原 真樹 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.小児科学]/[徳島大学.病院.診療科.小児·周産·女性科.小児科])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | 永井 隆
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | 藤岡 啓介 ([徳島大学.病院.診療科.小児·周産·女性科.小児科])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | 近藤 秀治
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | 木下 ゆき子
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Hattori Tomoki (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | 香美 祥二 ([徳島大学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Urinary angiotensin converting enzyme 2 and disease activity in pediatric IgA nephropathy (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Background : Our previous studies demonstrated that the intrarenal renin-angiotensin system (RAS) status was activated in pediatric patients with chronic glomerulonephritis. In the present study, we tested the hypothesis that angiotensin-converting enzyme 2 (ACE2) expression in the kidney is associated with the development of pediatric IgA nephropathy. Methods : We analyzed urinary ACE2 levels and ACE2 expression in the kidney tissues of pediatric patients with IgA nephropathy treated with RAS blockade. Paired tests were used to analyze changes from the first to the second biopsy. Results : Urinary ACE2 levels were significantly decreased after RAS blockade treatment, accompanied by decreased ACE2 expression levels in kidney tissues, urinary protein levels and mesangial hypercellularity scores. Urinary ACE2 levels at the first biopsy were positively correlated with the ACE2 expression levels. Conclusions : These data suggest that urinary ACE2 is associated with ACE2 expression in the diseased kidney, which correlates with the pathogenesis of IgA nephropathy in pediatric patients. J. Med. Invest. 68 : 292-296, August, 2021. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Angiotensin-Converting Enzyme 2 (日) (読)
| [継承] |
| 2. | (英) Biopsy (日) (読)
| [継承] |
| 3. | (英) Child (日) (読)
| [継承] |
| 4. | (英) Glomerulonephritis, IGA (日) (読)
| [継承] |
| 5. | (英) Humans (日) (読)
| [継承] |
| 6. | (英) Kidney (日) (読)
| [継承] |
| 7. | (英) Renin-Angiotensin System (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: Tokushima Daigaku Igakubu (NLM Catalog)
(Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 68
| [継承] |
| ○号 (必須): | □ | 3.4
| [継承] |
| ○頁 (必須): | □ | 292 296
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2021年 8月 初日 (令和 3年 8月 初日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.68.292 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 34759147 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85119281201
| [継承] |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.2152/jmi.68.292 (日)
| [継承] |
| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 3. | (英) KeywordList.Keyword: Angiotensin-converting enzyme 2 (日)
| [継承] |
| 4. | (英) KeywordList.Keyword: IgA nephropathy (日)
| [継承] |
| 5. | (英) KeywordList.Keyword: renin-angiotensin system (日)
| [継承] |