| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Murao Satoshi (日) (読)
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| 2. | 村尾 和俊 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.皮膚科学])
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| 3. | (英) Nagata Tsuyoshi (日) (読)
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| 4. | (英) Shimizu Misato (日) (読)
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| 5. | (英) Miyai Yumi (日) (読)
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| ○題名 (必須): | □ | (英) Repeated insulin injection without site rotation affects skin thickness - ultrasonographic and histological evaluation (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The influence of repeated insulin injection on subcutaneous tissue is known, but its impact on the skin is unclear. Therefore, this study aimed to elucidate the impact of repeated insulin injections on the skin. The properties of the skin and the subcutaneous tissue were evaluated in 52 insulin-treated adult patients with diabetes with abnormal findings at the site of self-injection (36 with subcutaneous nodules, 16 with suspected subcutaneous tissue induration) by ultrasonography. In all subjects, both normal and abnormal areas were examined. In addition, skin biopsies were performed in four subjects. The skin thickness of the normal and abnormal skin sites was 1.95 (1.60, 2.50) and 2.80 (2.27, 3.30) mm, respectively (median (first quartile, third quartile)), (P < 0.001). The biopsy specimens revealed slightly thickened and tight bundles of collagen in the dermis. Three patients had amyloid deposits in the subcutaneous tissue, and one also showed these in the dermis. These were positively stained for insulin antibody. Repeated insulin injection procedures result in skin thickening. Increased collagen fibers and possibly amyloid deposition in the dermis may be involved. The results reaffirmed the importance of appropriate site rotation in insulin injection and revealed the usefulness of ultrasonographic skin examination in evaluating the self-injection procedure. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Amyloidosis (日) (読)
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| 3. | (英) Collagen (日) (読)
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| 4. | (英) Humans (日) (読)
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| 5. | (英) Injections, Subcutaneous (日) (読)
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| 6. | (英) Insulin (日) (読)
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| 7. | (英) Rotation (日) (読)
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| 8. | (英) Skin (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Diabetes Investigation (Asian Association for the Study of Diabetes)
(pISSN: 2040-1116, eISSN: 2040-1124)
| ○ISSN (任意): | □ | 2040-1124
ISSN: 2040-1116
(pISSN: 2040-1116, eISSN: 2040-1124) Title: Journal of diabetes investigationTitle(ISO): J Diabetes InvestigPublisher: John Wiley and Sons Inc (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 13
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 997 1003
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 6月 初日 (令和 4年 6月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/jdi.13753 (→Scopusで検索)
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| ○PMID (任意): | □ | 35060349 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1111/jdi.13753 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Amyloidosis (日)
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| 4. | (英) KeywordList.Keyword: Lipohypertrophy (日)
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| 5. | (英) KeywordList.Keyword: Skin thickness (日)
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