| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): | □ | Peer Review
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| ○著者 (必須): | 1. | (英) Sezai A (日) (読)
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| 2. | (英) Tanaka A (日) (読)
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| 3. | (英) Imai T (日) (読)
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| 4. | (英) Kida K (日) (読)
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| 5. | (英) Sekino H (日) (読)
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| 6. | (英) Murohara T (日) (読)
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| 7. | 佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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| 8. | (英) Suzuki N (日) (読)
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| 9. | (英) Node K (日) (読)
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| ○題名 (必須): | □ | (英) Comparing the Effects of Canagliflozin vs. Glimepiride by Body Mass Index in Patients with Type 2 Diabetes and Chronic Heart Failure: A Subanalysis of the CANDLE Trial (日)
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| ○要約 (任意): | □ | (英) We present results of a 24-week comparative study of the effects of the sodium-glucose cotransporter 2 (SGLT2) inhibitor canagliflozin vs. the sulfonylurea glimepiride, by baseline body mass index (BMI), in patients with type 2 diabetes and chronic heart failure. We conducted a post hoc analysis of the CANDLE trial. This subanalysis evaluated NT-proBNP, BMI, and other laboratory parameters, according to the subgroups stratified by BMI ≥ 25 kg/m vs. BMI < 25 kg/m. A group ratio of proportional changes in the geometric means of NT-proBNP was 0.99 ( = 0.940) for the subgroup with BMI ≥ 25 kg/m and 0.85 ( = 0.075) for the subgroup with BMI < 25 kg/m, respectively. When baseline BMI was modeled as a continuous variable, results for patients with BMI < 30 kg/m showed a slightly smaller increase in NT-proBNP in the canagliflozin group vs. the glimepiride group ( = 0.295); that difference was not seen among patients with BMI ≥30 kg/m ( = 0.948). Irrespective of obesity, the canagliflozin group was associated with significant reduction in BMI compared to the glimepiride group. There was no significant difference in the effects of canagliflozin, relative to glimepiride, on NT-proBNP concentrations irrespective of baseline obesity. UMIN clinical trial registration number: UMIN000017669. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Biomedicines (MDPI AG)
(eISSN: 2227-9059)
| ○ISSN (任意): | □ | 2227-9059
ISSN: 2227-9059
(eISSN: 2227-9059) Title: BiomedicinesTitle(ISO): BiomedicinesPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 10
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 1656 1656
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| ○年月日 (必須): | □ | 西暦 2022年 7月 9日 (令和 4年 7月 9日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/biomedicines10071656 (→Scopusで検索)
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| ○PMID (任意): | □ | 35884961 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 1656 (日)
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| 2. | (英) Article.ELocationID: 10.3390/biomedicines10071656 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: BMI (日)
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| 5. | (英) KeywordList.Keyword: NT-proBNP (日)
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| 6. | (英) KeywordList.Keyword: diabetes (日)
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| 7. | (英) KeywordList.Keyword: heart failure (日)
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| 8. | (英) KeywordList.Keyword: sodium-glucose transporter 2 inhibitors (日)
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