| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | 西嶋 仁
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| 2. | (英) Sugita Mizuki (日) (読)
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| 3. | (英) Umezawa Natsuka (日) (読)
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| 4. | (英) Kimura Naoki (日) (読)
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| 5. | (英) Sasaki Hirokazu (日) (読)
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| 6. | 河野 弘 ([徳島大学.病院.診療科.内科.呼吸器・膠原病内科])
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| 7. | 西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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| 8. | 松本 穣 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.分子病理学])
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| 9. | 尾矢 剛志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.分子病理学])
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| 10. | 常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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| 11. | 森本 純子 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 12. | 松本 満
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| ○題名 (必須): | □ | (英) Development of organ-specific autoimmunity by dysregulated Aire expression. (日)
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| ○要約 (任意): | □ | (英) cells expressing AIRE in the peripheral blood before the treatment but not during the remission phase treated with immunosuppressive drugs. Thus, not only loss of function of AIRE/Aire but also augmented and/or dysregulated expression of AIRE/Aire should be considered for the pathogenesis of organ-specific autoimmunity. We suggest that further analyses should be pursued to establish a novel link between organ-specific autoimmune disease and dysregulated AIRE expression in clinical settings. (日) Deficiency for AIRE/Aire in both humans and mice results in the development of organ-specific autoimmune disease. We tested whether augmented and/or dysregulated AIRE/Aire expression might be also prone to the breakdown of self-tolerance. To define the effect of augmented Aire expression on the development of autoimmunity, antigen-specific clonal deletion and production of clonotypic regulatory T cells (Tregs) in the thymus were examined using mice expressing two additional copies of Aire in a heterozygous state (3xAire-knockin mice: 3xAire-KI). We found that both clonal deletion of autoreactive T cells and production of clonotypic Tregs in the thymus from 3xAire-KI were impaired in a T-cell receptor-transgenic system. Furthermore, 3xAire-KI females showed higher scores of experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein than wild-type littermates, suggesting that augmented Aire expression exacerbates organ-specific autoimmunity under disease-prone conditions. In humans, we found that one patient with amyopathic dermatomyositis showed CD3
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | 自己免疫 (autoimmunity)
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| 3. | (英) Clonal Deletion (日) (読)
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| 4. | (英) Encephalomyelitis, Autoimmune, Experimental (日) (読)
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| 5. | 女性 (female)
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| 6. | (英) Humans (日) (読)
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| 7. | (英) Immune Tolerance (日) (読)
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| 8. | (英) Mice (日) (読)
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| 9. | (英) Myelin-Oligodendrocyte Glycoprotein (日) (読)
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| 10. | (英) Thymus Gland (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Immunology and Cell Biology (Australian Society for Immunology)
(pISSN: 0818-9641, eISSN: 1440-1711)
| ○ISSN (任意): | □ | 1440-1711
ISSN: 0818-9641
(pISSN: 0818-9641, eISSN: 1440-1711) Title: Immunology and cell biologyTitle(ISO): Immunol Cell BiolSupplier: Australian and New Zealand Society for ImmunologyPublisher: Wiley (NLM Catalog)
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(Scopus)
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| ○巻 (必須): | □ | 100
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 371 377
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| ○年月日 (必須): | □ | 西暦 2022年 4月 9日 (令和 4年 4月 9日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/imcb.12546 (→Scopusで検索)
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| ○PMID (任意): | □ | 35313042 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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