『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=387240EID:387240, Map:0, LastModified:2022年7月26日(火) 13:42:49, Operator:[西岡 安彦], Avail:TRUE, Censor:承認済, Owner:[西岡 安彦], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨):
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1.荻野 広和 ([徳島大学.病院.診療科.内科.呼吸器・膠原病内科])
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○学籍番号 (推奨):
[継承]
2. (英) Taylor Jennie W (日) (読)
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○学籍番号 (推奨):
[継承]
3. (英) Nejo Takahide (日) (読)
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[継承]
4. (英) Gibson David (日) (読)
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[継承]
5. (英) Watchmaker Payal B (日) (読)
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[継承]
6. (英) Okada Kaori (日) (読)
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7.西條 敦郎
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8. (英) Tedesco Meghan R (日) (読)
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9. (英) Shai Anny (日) (読)
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10. (英) Wong Cynthia M (日) (読)
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11. (英) Rabbitt Jane E (日) (読)
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12. (英) Olin Michael R (日) (読)
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13. (英) Moertel Christopher L (日) (読)
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14.西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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15. (英) Salazar Andres M (日) (読)
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16. (英) Molinaro Annette M (日) (読)
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17. (英) Phillips Joanna J (日) (読)
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18. (英) Butowski Nicholas A (日) (読)
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19. (英) Clarke Jennifer L (日) (読)
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20. (英) Oberheim Bush Nancy Ann (日) (読)
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21. (英) Hervey-Jumper Shawn L (日) (読)
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22. (英) Theodosopoulos Philip (日) (読)
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23. (英) Chang Susan M (日) (読)
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24. (英) Berger Mitchel S (日) (読)
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25. (英) Okada Hideho (日) (読)
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○題名 (必須): □(英) Randomized trial of neoadjuvant vaccination with tumor-cell lysate induces T cell response in low-grade gliomas.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) BACKGROUNDLong-term prognosis of WHO grade II low-grade gliomas (LGGs) is poor, with a high risk of recurrence and malignant transformation into high-grade gliomas. Given the relatively intact immune system of patients with LGGs and the slow tumor growth rate, vaccines are an attractive treatment strategy.METHODSWe conducted a pilot study to evaluate the safety and immunological effects of vaccination with GBM6-AD, lysate of an allogeneic glioblastoma stem cell line, with poly-ICLC in patients with LGGs. Patients were randomized to receive the vaccines before surgery (arm 1) or not (arm 2) and all patients received adjuvant vaccines. Coprimary outcomes were to evaluate safety and immune response in the tumor.RESULTSA total of 17 eligible patients were enrolled - 9 in arm 1 and 8 in arm 2. This regimen was well tolerated with no regimen-limiting toxicity. Neoadjuvant vaccination induced upregulation of type-1 cytokines and chemokines and increased activated CD8+ T cells in peripheral blood. Single-cell RNA/T cell receptor sequencing detected CD8+ T cell clones that expanded with effector phenotype and migrated into the tumor microenvironment (TME) in response to neoadjuvant vaccination. Mass cytometric analyses detected increased tissue resident-like CD8+ T cells with effector memory phenotype in the TME after the neoadjuvant vaccination.CONCLUSIONThe regimen induced effector CD8+ T cell response in peripheral blood and enabled vaccine-reactive CD8+ T cells to migrate into the TME. Further refinements of the regimen may have to be integrated into future strategies.TRIAL REGISTRATIONClinicalTrials.gov NCT02549833.FUNDINGNIH (1R35NS105068, 1R21CA233856), Dabbiere Foundation, Parker Institute for Cancer Immunotherapy, and Daiichi Sankyo Foundation of Life Science.  (日)    [継承]
○キーワード (推奨): 1.成人 (adult) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) CD8-Positive T-Lymphocytes (日) (読) [継承]
4. (英) Cancer Vaccines (日) (読) [継承]
5. (英) Carboxymethylcellulose Sodium (日) (読) [継承]
6.女性 (female) [継承]
7. (英) Glioma (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9.男性 (male) [継承]
10. (英) Middle Aged (日) (読) [継承]
11. (英) Neoadjuvant Therapy (日) (読) [継承]
12. (英) Poly I-C (日) (読) [継承]
13. (英) Polylysine (日) (読) [継承]
14. (英) Tumor Microenvironment (日) (読) [継承]
15. (英) Vaccination (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □The Journal of Clinical Investigation (The American Society for Clinical Investigation (ASCI))
(pISSN: 0021-9738, eISSN: 1558-8238)

○ISSN (任意): □1558-8238
ISSN: 0021-9738 (pISSN: 0021-9738, eISSN: 1558-8238)
Title: The Journal of clinical investigation
Title(ISO): J Clin Invest
Publisher: American Society for Clinical Investigation
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □132 [継承]
○号 (必須): □3 [継承]
○頁 (必須): □ [継承]
○都市 (任意):
○年月日 (必須): □西暦 2022年 2月 1日 (令和 4年 2月 1日) [継承]
○URL (任意):
○DOI (任意): □10.1172/JCI151239    (→Scopusで検索) [継承]
○PMID (任意): □34882581    (→Scopusで検索) [継承]
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○備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Randomized Controlled Trial  (日)    [継承]
3.(英) PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
4.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hirokazu Ogino, W Jennie Taylor, Takahide Nejo, David Gibson, B Payal Watchmaker, Kaori Okada, Atsuro Saijo, R Meghan Tedesco, Anny Shai, M Cynthia Wong, E Jane Rabbitt, R Michael Olin, L Christopher Moertel, Yasuhiko Nishioka, M Andres Salazar, M Annette Molinaro, J Joanna Phillips, A Nicholas Butowski, L Jennifer Clarke, Ann Bush Nancy Oberheim, L Shawn Hervey-Jumper, Philip Theodosopoulos, M Susan Chang, S Mitchel Berger and Hideho Okada : Randomized trial of neoadjuvant vaccination with tumor-cell lysate induces T cell response in low-grade gliomas., The Journal of Clinical Investigation, Vol.132, No.3, 2022.
欧文冊子 ● Hirokazu Ogino, W Jennie Taylor, Takahide Nejo, David Gibson, B Payal Watchmaker, Kaori Okada, Atsuro Saijo, R Meghan Tedesco, Anny Shai, M Cynthia Wong, E Jane Rabbitt, R Michael Olin, L Christopher Moertel, Yasuhiko Nishioka, M Andres Salazar, M Annette Molinaro, J Joanna Phillips, A Nicholas Butowski, L Jennifer Clarke, Ann Bush Nancy Oberheim, L Shawn Hervey-Jumper, Philip Theodosopoulos, M Susan Chang, S Mitchel Berger and Hideho Okada : Randomized trial of neoadjuvant vaccination with tumor-cell lysate induces T cell response in low-grade gliomas., The Journal of Clinical Investigation, Vol.132, No.3, 2022.

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