| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
| [継承] |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない))
| [継承] |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Khatun Anowara (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Hasan Mahadi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) El-Emam Abd Mohamed Mahran (日) MAHRAN MONAMED ABDELEMAM MAHRAN (読) まはらん もはめど あぶどえるえまむ まはらん
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 4. | 福田 達也
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Mimura Miyuki (日) 三村 美夕紀 (読) みむら みゆき
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 6. | (英) Tashima Riho (日) 田嶋 里帆 (読) たしま りほ
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 7. | 米田 晋太朗 ([徳島大学.大学院医歯薬学研究部.薬学域.先端薬学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 8. | (英) Yoshimi Shintaroh (日) 吉見 真太朗 (読) よしみ しんたろう
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 9. | 小暮 健太朗 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Effective Anticancer Therapy by Combination of Nanoparticles Encapsulating Chemotherapeutic Agents and Weak Electric Current (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Delivery of medicines using nanoparticles via the enhanced permeability and retention (EPR) effect is a common strategy for anticancer chemotherapy. However, the extensive heterogeneity of tumors affects the applicability of the EPR effect, which needs to overcome for effective anticancer therapy. Previously, we succeeded in the noninvasive transdermal delivery of nanoparticles by weak electric current (WEC) and confirmed that WEC regulates the intercellular junctions in the skin by activating cell signaling pathways (J. Biol. Chem., 289, 2014, Hama et al.). In this study, we applied WEC to tumors and investigated the EPR effect with polyethylene glycol (PEG)-modified doxorubicin (DOX) encapsulated nanoparticles (DOX-NP) administered via intravenous injection into melanoma-bearing mice. The application of WEC resulted in a 2.3-fold higher intratumor accumulation of nanoparticles. WEC decreased the amount of connexin 43 in tumors while increasing its phosphorylation; therefore, the enhancing of intratumor delivery of DOX-NP is likely due to the opening of gap junctions. Furthermore, WEC combined with DOX-NP induced a significant suppression of tumor growth, which was stronger than with DOX-NP alone. In addition, WEC alone showed tumor growth inhibition, although it was not significant compared with non-treated group. These results are the first to demonstrate that effective anticancer therapy by combination of nanoparticles encapsulating chemotherapeutic agents and WEC. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
| [継承] |
| 2. | (英) Antineoplastic Agents (日) (読)
| [継承] |
| 3. | (英) Doxorubicin (日) (読)
| [継承] |
| 4. | (英) Drug Delivery Systems (日) (読)
| [継承] |
| 5. | (英) Electrochemical Techniques (日) (読)
| [継承] |
| 6. | 男性 (male)
| [継承] |
| 7. | (英) Melanoma (日) (読)
| [継承] |
| 8. | (英) Mice (日) (読)
| [継承] |
| 9. | (英) Mice, Inbred C57BL (日) (読)
| [継承] |
| 10. | ナノ粒子 (nanoparticles/->キーワード[ナノ粒子])
| [継承] |
| 11. | (英) Neoplasms, Experimental (日) (読)
| [継承] |
| 12. | (英) Xenograft Model Antitumor Assays (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biological & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0918-6158, eISSN: 1347-5215)
| ○ISSN (任意): | □ | 1347-5215
ISSN: 0918-6158
(pISSN: 0918-6158, eISSN: 1347-5215) Title: Biological & pharmaceutical bulletinTitle(ISO): Biol Pharm BullSupplier: 公益社団法人日本薬学会Publisher: Pharmaceutical Society of Japan (NLM Catalog)
(Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 45
| [継承] |
| ○号 (必須): | □ | 2
| [継承] |
| ○頁 (必須): | □ | 194 199
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 1月 初日 (令和 4年 1月 初日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1248/bpb.b21-00714 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 35110506 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85123844154
| [継承] |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): | 1. | 小暮 健太朗 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
| [継承] |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1248/bpb.b21-00714 (日)
| [継承] |
| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 3. | (英) KeywordList.Keyword: anticancer therapy (日)
| [継承] |
| 4. | (英) KeywordList.Keyword: enhanced permeability and retention effect (日)
| [継承] |
| 5. | (英) KeywordList.Keyword: nanoparticle (日)
| [継承] |
| 6. | (英) KeywordList.Keyword: weak electric current (日)
| [継承] |