『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Yamaguchi Takashi (日) (読)
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[継承]
2. (英) Yoshida Katsunori (日) (読)
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[継承]
3. (英) Murata Miki (日) (読)
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[継承]
4. (英) Suwa Kanehiko (日) (読)
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5.常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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[継承]
6. (英) Matsuzaki Koichi (日) (読)
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[継承]
7. (英) Naganuma Makoto (日) (読)
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[継承]
題名 (必須): (英) Smad3 Phospho-Isoform Signaling in Nonalcoholic Steatohepatitis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis with insulin resistance, oxidative stress, lipotoxicity, adipokine secretion by fat cells, endotoxins (lipopolysaccharides) released by gut microbiota, and endoplasmic reticulum stress. Together, these factors promote NAFLD progression from steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and eventually end-stage liver diseases in a proportion of cases. Hepatic fibrosis and carcinogenesis often progress together, sharing inflammatory pathways. However, NASH can lead to hepatocarcinogenesis with minimal inflammation or fibrosis. In such instances, insulin resistance, oxidative stress, and lipotoxicity can directly lead to liver carcinogenesis through genetic and epigenetic alterations. Transforming growth factor (TGF)-β signaling is implicated in hepatic fibrogenesis and carcinogenesis. TGF-β type I receptor (TβRI) and activated-Ras/c-Jun-N-terminal kinase (JNK) differentially phosphorylate the mediator Smad3 to create two phospho-isoforms: C-terminally phosphorylated Smad3 (pSmad3C) and linker-phosphorylated Smad3 (pSmad3L). TβRI/pSmad3C signaling terminates cell proliferation, while constitutive Ras activation and JNK-mediated pSmad3L promote hepatocyte proliferation and carcinogenesis. The pSmad3L signaling pathway also antagonizes cytostatic pSmad3C signaling. This review addresses TGF-β/Smad signaling in hepatic carcinogenesis complicating NASH. We also discuss Smad phospho-isoforms as biomarkers predicting HCC in NASH patients with or without cirrhosis.  (日)    [継承]
キーワード (推奨): 1. (英) Carcinogenesis (日) (読) [継承]
2. (英) Carcinoma, Hepatocellular (日) (読) [継承]
3. (英) Humans (日) (読) [継承]
4. (英) Insulin Resistance (日) (読) [継承]
5. (英) Liver Cirrhosis (日) (読) [継承]
6. (英) Liver Neoplasms (日) (読) [継承]
7. (英) Non-alcoholic Fatty Liver Disease (日) (読) [継承]
8. (英) Protein Isoforms (日) (読) [継承]
9. (英) Signal Transduction (日) (読) [継承]
10. (英) Smad3 Protein (日) (読) [継承]
11. (英) Transforming Growth Factor beta (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Molecular Sciences (Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(pISSN: 1661-6596, eISSN: 1422-0067)

ISSN (任意): 1422-0067
ISSN: 1661-6596 (pISSN: 1661-6596, eISSN: 1422-0067)
Title: International journal of molecular sciences
Title(ISO): Int J Mol Sci
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 23 [継承]
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年月日 (必須): 西暦 2022年 6月 3日 (令和 4年 6月 3日) [継承]
URL (任意):
DOI (任意): 10.3390/ijms23116270    (→Scopusで検索) [継承]
PMID (任意): 35682957    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Review  (日)    [継承]

標準的な表示

和文冊子 ● Takashi Yamaguchi, Katsunori Yoshida, Miki Murata, Kanehiko Suwa, Koichi Tsuneyama, Koichi Matsuzaki and Makoto Naganuma : Smad3 Phospho-Isoform Signaling in Nonalcoholic Steatohepatitis., International Journal of Molecular Sciences, Vol.23, No.11, (頁), 2022.
欧文冊子 ● Takashi Yamaguchi, Katsunori Yoshida, Miki Murata, Kanehiko Suwa, Koichi Tsuneyama, Koichi Matsuzaki and Makoto Naganuma : Smad3 Phospho-Isoform Signaling in Nonalcoholic Steatohepatitis., International Journal of Molecular Sciences, Vol.23, No.11, (頁), 2022.

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