| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Yamanaka Ayaka (日) 山中 彩夏 (読) やまなか あやか
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 山田 苑子 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学]/[徳島大学.医学部.医科栄養学科.臨床実践栄養学講座.代謝栄養学]/->個人[安井 苑子])
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| 3. | (英) Furumoto Taiki (日) 古本 太希 (読) ふるもと たいき
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| ○学籍番号 (推奨): | □ | ****
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| 4. | (英) Kubo Miyu (日) 久保 みゆ (読) くぼ みゆ
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| ○学籍番号 (推奨): | □ | ****
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| 5. | (英) Hayashi Haruka (日) 林 遼 (読) はやし はるか
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| ○学籍番号 (推奨): | □ | ****
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| 6. | (英) Kitao Midori (日) 北尾 緑 (読) きたお みどり
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| ○学籍番号 (推奨): | □ | ****
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| 7. | (英) Wada Kyoko (日) 和田 京子 (読) わだ きょうこ
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| ○学籍番号 (推奨): | □ | ****
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| 8. | (英) Ohmae Nao (日) 大前 奈央 (読) おおまえ なお
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| ○学籍番号 (推奨): | □ | ****
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| 9. | 神村 盛一郎 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.感覚·皮膚·運動機能科.耳鼻咽喉科・頭頸部外科])
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| 10. | 島田 亜紀
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| 11. | 佐藤 紀 ([徳島大学.病院.中央診療施設等.リハビリテーション部])
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| 12. | 加藤 真介
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| 13. | 武田 憲昭
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| 14. | 濵田 康弘 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.疾患治療栄養学])
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| ○題名 (必須): | □ | (英) Association of phase angle with muscle function and prognosis in patients with head and neck cancer undergoing chemoradiotherapy (日)
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| ○要約 (任意): | □ | (英) (日) Objective: We aimed to investigate the correlation of phase angle (PhA) with other parameters (e.g., muscle mass/quality/strength and physical function), assess the prognostic relevance of pre-chemoradiotherapy (CRT) PhA, and suggest a reference value of PhA in Asian patients with head and neck cancer (HNC). Research Methods & Procedures: Ninety-six patients with HNC who underwent CRT were divided into two groups, maintained-PhA group and low-PhA group, according to the PhA 25th percentile values by sex. Pretreatment PhA was measured using direct segmental multi-frequency bioelectrical impedance analysis, and muscle quality was assessed using echo intensity in ultrasound images. Correlation of PhA with other parameters was investigated, and between-group differences with respect to adverse events, treatment interruption, and 3-year survival were assessed. Results: PhA showed a positive correlation with isometric knee extension force (R = 0.710), handgrip strength (R = 0.649), skeletal muscle mass index (R = 0.620), and maximum gait speed (R = 0.543) (P < 0.001). PhA showed a negative correlation with echo intensity (R = -0.439) and five times sit-to-stand test (R = -0.505) (P < 0.01). The low-PhA group had a higher incidence of severe anemia (52% in low-PhA vs. 17% in maintained-PhA), aspiration (17% vs. 1%), radiotherapy interruption (17% vs. 3%), and poor 3-year survival (47% vs. 81%) than the maintained-PhA group (P < 0.05). Conclusion: PhA was correlated with muscle mass/quality/strength, and physical function. Low PhA was associated with severe adverse events, treatment interruption, and shorter survival. These findings suggested that 4.6° for men and 4.0° for women may be useful as prognostic reference values in Asian patients with HNC.
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| ○キーワード (推奨): | 1. | (英) Phase angle (日) (読)
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| 2. | (英) Muscle strength (日) (読)
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| 3. | (英) Muscle quality (日) (読)
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| 4. | (英) Physical function (日) (読)
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| 5. | (英) Prognosis (日) (読)
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| 6. | (英) Head and neck cancer (日) (読)
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| ○発行所 (推奨): | □ | (英) Elsevier (日) (読)
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| ○誌名 (必須): | □ | Nutrition ([Elsevier])
(pISSN: 0899-9007, eISSN: 1873-1244)
| ○ISSN (任意): | □ | 0899-9007
ISSN: 0899-9007
(pISSN: 0899-9007, eISSN: 1873-1244) Title: Nutrition (Burbank, Los Angeles County, Calif.)Title(ISO): NutritionPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ |
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 111798 111798
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| ○年月日 (必須): | □ | 西暦 2022年 7月 19日 (令和 4年 7月 19日)
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| ○URL (任意): | □ | http://repo.lib.tokushima-u.ac.jp/117379
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| ○DOI (任意): | □ | 10.1016/j.nut.2022.111798 (→Scopusで検索)
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| ○PMID (任意): |
| ○CRID (任意): | □ | 1050584022353400832
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