| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Chavan P (日) CHAVAN PARIMAL RAVINDRA (読) ぱりまる らびんどら ちゃばん
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 近久 幸子
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| 3. | 志内 哲也
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| 4. | 清水 紀之
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| 5. | (英) Dalanon Junhel (日) Dalanon Junhel Casinillo (読) だらのん じゅねる かしにりよ
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| ○学籍番号 (推奨): | □ | ****
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| 6. | 大倉 一夫
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| 7. | 勢井 宏義
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| 8. | 松香 芳三 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.顎機能咬合再建学])
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| ○題名 (必須): | □ | (英) Dual orexin receptor antagonist drug suvorexant can help in amelioration of predictable chronic mild stress-induced hyperalgesia (日)
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| ○要約 (任意): | □ | (英) This study aimed to evaluate the involvement of the orexin system in predictable chronic mild stress (PCMS) and the effects of suvorexant, a dual orexin receptor antagonist, on nociceptive behavior in PCMS. Male C57BL/6 J mice were separated into various PCMS groups: a control group with sawdust on the floor of the rearing cage (C), a group with mesh wire on the floor (M), and a group with water just below the mesh wire (W). Activation of lateral hypothalamic orexin neurons was assessed using immunofluorescence. In another experiment, half of the mice in each group were administered an intraperitoneal injection of suvorexant (10 mg/kg), and the remaining mice were injected with the same amount of vehicle (normal saline). Thermal hyperalgesia was examined using tail immersion and hot plate tests, while mechanical hyperalgesia was investigated using the tail pinch test after 21 days of PCMS. Animals subjected to PCMS showed an increased percentage of activated orexin neurons in the lateral hypothalamic region after 21 days. Mice raised in the PCMS environment showed increased pain sensitivity in several pain tests; however, the symptoms were significantly reduced by suvorexant administration. The findings revealed that PCMS activates hypothalamic orexin neuronal activity, and the use of suvorexant can help attenuate PCMS-induced thermal and mechanical hyperalgesia. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Brain Research Bulletin ([Elsevier])
(pISSN: 0361-9230, eISSN: 1873-2747)
| ○ISSN (任意): | □ | 1873-2747
ISSN: 0361-9230
(pISSN: 0361-9230, eISSN: 1873-2747) Title: Brain research bulletinTitle(ISO): Brain Res BullPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 188
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 39 46
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 7月 19日 (令和 4年 7月 19日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.brainresbull.2022.07.011 (→Scopusで検索)
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| ○PMID (任意): | □ | 35868501 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: S0361-9230(22)00174-5 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.brainresbull.2022.07.011 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Hyperalgesia (日)
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| 5. | (英) KeywordList.Keyword: Orexin (日)
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| 6. | (英) KeywordList.Keyword: Predictable chronic mild stress (PCMS) (日)
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| 7. | (英) KeywordList.Keyword: Suvorexant (日)
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