| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 日本語
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 単独著作 (徳島大学内の単一の研究グループ(研究室等)内の研究 (単著も含む))
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| ○学究種別 (推奨): |
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| ○著者 (必須): | 1. | (英) Matsuda Hiroya (日) 松田 宙也 (読) まつだ ひろや
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| 2. | 倉橋 清衛
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| 3. | (英) Endo Furi (日) 遠藤 ふうり (読) えんどう ふうり
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| 4. | (英) Masuda Shiho (日) 桝田 志保 (読) ますだ しほ
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| 5. | (英) (日) (読)
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| ○学籍番号 (推奨): | □ | ****
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| 6. | (英) Mitsui Yukari (日) 三井 由加里 (読) みつい ゆかり
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| 7. | 吉田 守美子
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| 8. | (英) Akehi Yuko (日) 明比 祐子 (読) あけひ ゆうこ
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| 9. | 遠藤 逸朗 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.生体機能解析学])
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| 10. | 福本 誠二
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| ○題名 (必須): | □ | (英) A case of isolated ACTH deficiency that required 6 months for the diagnosis from onset. (日) 症状発現から診断までに半年を要したACTH単独欠損症の一例
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) (日) A 53-year-old man noticed anorexia, nausea, and arthralgia of the upper limbs in April, 201X. Since these symptoms persisted, he visited general hospital and clinic and was examined for blood chemistry, ECG, echocardiography and so on. However, he did not get a definitive diagnosis and was followed up with drip infusion of saline. The symptoms did not subside and fatigue and syncope with hypotension developed. Furthermore, he also suffered weight loss of 10 kg in few months and was referred to our hospital for more detailed examinations in October, 201X. Upon the initial examination, all his symptoms matched those of adrenal insufficiency and notable decreases of both plasma ACTH and serum cortisol level were observed. Prompt glucocorticoid supplementation improved his symptoms and the abnormal laboratory data immediately. He was diagnosed adrenal insufficiency due to isolated ACTH deficiency from the results of CRH loading test and insulin tolerance test. Since most of the symptoms and laboratory findings are non-specific, diagnosis of adrenal insufficiency is often delayed. However, adrenal insufficiency could worsen when the patient is under stress (e.g. infection) and often be life-threatening. Glucocorticoid replacement therapy should be initiated as soon as the diagnosis is confirmed. Furthermore, educating patients and his families plays a very important role in the management of chronic adrenal insufficiency, in particular to the prevention of adrenal crisis.
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| ○キーワード (推奨): | 1. | (英) isolated ACTH deficiency (日) (読)
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| 2. | (英) adrenal insufficiency (日) (読)
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| 3. | (英) anorexia (日) (読)
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| 4. | (英) nausea (日) (読)
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| 5. | (英) arthralgia (日) (読)
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| ○発行所 (推奨): | □ | 徳島医学会
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| ○誌名 (必須): | □ | 四国医学雑誌 ([徳島医学会])
(pISSN: 0037-3699, eISSN: 2758-3279)
| ○ISSN (任意): | □ | 0037-3699
ISSN: 0037-3699
(pISSN: 0037-3699, eISSN: 2758-3279) Title: 四国医学雑誌Supplier: 徳島大学Publisher: Tokushima Igakkai (Webcat Plus)
(医中誌Web)
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(Scopus)
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| ○巻 (必須): | □ | 75
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| ○号 (必須): | □ | 1, 2
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| ○頁 (必須): | □ | 69 74
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2019年 4月 25日 (平成 31年 4月 25日)
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| ○URL (任意): | □ | http://repo.lib.tokushima-u.ac.jp/113765
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| ○DOI (任意): |
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| ○CRID (任意): | □ | 1050845763703567104
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| ○NAID : | □ | 120006729382
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| ○指導教員 (推奨): | 1. | 倉橋 清衛
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