| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): | □ | Peer Review
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| ○著者 (必須): | 1. | (英) Okushi Y (日) 大櫛 祐一郎 (読) おおくし ゆういちろう
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 楠瀬 賢也
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| 3. | (英) Nakai M (日) (読)
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| 4. | (英) Sumita Y (日) (読)
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| 5. | 伊勢 孝之 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.循環器内科])
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| 6. | 山口 浩司 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学]/[徳島大学.病院.診療科.内科.循環器内科])
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| 7. | 八木 秀介 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.地域・家庭医療学])
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| 8. | 福田 大受
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| 9. | 山田 博胤 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
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| 10. | 添木 武 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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| 11. | 若槻 哲三
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| 12. | 佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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| ○題名 (必須): | □ | (英) Comparison of Direct Oral Anticoagulants for Acute Hospital Mortality in Venous Thromboembolism (日)
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| ○要約 (任意): | □ | (英) The choice of direct oral anticoagulants (DOACs) for venous thromboembolism (VTE) is at the physician's discretion; however, it is useful to know the differences in the clinical data of DOACs to help physicians choose. We aimed to compare the mortality associated with the use of rivaroxaban, edoxaban, and apixaban in clinical practice. We identified 38,245 patients with first hospitalization for VTE from the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). We classified patients into three groups by DOAC (rivaroxaban and edoxaban group, rivaroxaban and apixaban group, and edoxaban and apixaban group) and compared the in-hospital mortality and bleeding risk by propensity score (PS) matching in each group. After PS matching, patients with rivaroxaban use had significantly lower total in-hospital mortality (1.2% vs. 2.1%; odds ratio [OR] 0.55, p = 0.012) and in-hospital mortality within 21 days (0.4% vs. 1.0%; OR 0.41, p = 0.020) and 28 days (0.7% vs. 1.3%; OR 0.53, p = 0.042) than patients with apixaban use. In the subanalysis, significant differences were only observed in patients younger than 80 years of age, patients with pulmonary embolism, and patients without heart failure. There was no significant difference in in-hospital mortality in the other groups and in the rate of bleeding events among the three groups. On PS-matched analysis, there was a difference in in-hospital mortality, especially in the rivaroxaban and apixaban group. Identifying the clinical characteristics of patients associated with each DOAC, as well as prognosis, will be useful in determining treatment strategies for VTE. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | American Journal of Cardiovascular Drugs (Springer International)
(pISSN: 1175-3277, eISSN: 1179-187X)
| ○ISSN (任意): | □ | 1179-187X
ISSN: 1175-3277
(pISSN: 1175-3277, eISSN: 1179-187X) Title: American journal of cardiovascular drugs : drugs, devices, and other interventionsTitle(ISO): Am J Cardiovasc DrugsPublisher: Adis (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 22
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 407 416
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 7月 初日 (令和 4年 7月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s40256-021-00514-5 (→Scopusで検索)
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| ○PMID (任意): | □ | 34927214 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s40256-021-00514-5 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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