『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=382838EID:382838, Map:0, LastModified:2021年10月27日(水) 19:09:11, Operator:[駒 貴明], Avail:TRUE, Censor:0, Owner:[駒 貴明], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.駒 貴明 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.微生物病原学])
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2.土肥 直哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.微生物病原学])
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3. (英) Takemoto Mai (日) (読)
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4. (英) Watanabe Kyosuke (日) (読)
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5. (英) Yamamoto Hideki (日) (読)
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6. (英) Nakashima Satoshi (日) (読)
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7.足立 昭夫
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8.野間口 雅子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.微生物病原学])
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題名 (必須): (英) The Expression Level of HIV-1 Vif Is Optimized by Nucleotide Changes in the Genomic SA1D2prox Region during the Viral Adaptation Process.  (日)    [継承]
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要約 (任意): (英) HIV-1 Vif plays an essential role in viral replication by antagonizing anti-viral cellular restriction factors, a family of APOBEC3 proteins. We have previously shown that naturally-occurring single-nucleotide mutations in the SA1D2prox region, which surrounds the splicing acceptor 1 and splicing donor 2 sites of the HIV-1 genome, dramatically alter the Vif expression level, resulting in variants with low or excessive Vif expression. In this study, we investigated how these HIV-1 variants with poor replication ability adapt and evolve under the pressure of APOBEC3 proteins. Adapted clones obtained through adaptation experiments exhibited an altered replication ability and Vif expression level compared to each parental clone. While various mutations were present throughout the viral genome, all replication-competent adapted clones with altered Vif expression levels were found to bear them within SA1D2prox, without exception. Indeed, the mutations identified within SA1D2prox were responsible for changes in the Vif expression levels and altered the splicing pattern. Moreover, for samples collected from HIV-1-infected patients, we showed that the nucleotide sequences of SA1D2prox can be chronologically changed and concomitantly affect the Vif expression levels. Taken together, these results demonstrated the importance of the SA1D2prox nucleotide sequence for modulating the Vif expression level during HIV-1 replication and adaptation.  (日)    [継承]
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誌名 (必須): Viruses (Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(eISSN: 1999-4915)

ISSN (任意): 1999-4915
ISSN: 1999-4915 (eISSN: 1999-4915)
Title: Viruses
Title(ISO): Viruses
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
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(必須): 13 [継承]
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年月日 (必須): 西暦 2021年 10月 15日 (令和 3年 10月 15日) [継承]
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DOI (任意): 10.3390/v13102079    (→Scopusで検索) [継承]
PMID (任意): 34696508    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Takaaki Koma, Naoya Doi, Mai Takemoto, Kyosuke Watanabe, Hideki Yamamoto, Satoshi Nakashima, Akio Adachi and Masako Nomaguchi : The Expression Level of HIV-1 Vif Is Optimized by Nucleotide Changes in the Genomic SA1D2prox Region during the Viral Adaptation Process., Viruses, Vol.13, No.10, (頁), 2021.
欧文冊子 ● Takaaki Koma, Naoya Doi, Mai Takemoto, Kyosuke Watanabe, Hideki Yamamoto, Satoshi Nakashima, Akio Adachi and Masako Nomaguchi : The Expression Level of HIV-1 Vif Is Optimized by Nucleotide Changes in the Genomic SA1D2prox Region during the Viral Adaptation Process., Viruses, Vol.13, No.10, (頁), 2021.

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