| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 楠瀬 賢也
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| 2. | (英) Imai T (日) (読)
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| 3. | (英) Tanaka A (日) (読)
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| 4. | (英) Dohi K (日) (読)
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| 5. | (英) Shiina K (日) (読)
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| 6. | (英) Yamada T (日) (読)
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| 7. | (英) Kida K (日) (読)
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| 8. | (英) Eguchi K (日) (読)
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| 9. | (英) Teragawa H (日) (読)
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| 10. | (英) Takeishi Y (日) (読)
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| 11. | (英) Ohte N (日) (読)
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| 12. | 山田 博胤 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
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| 13. | 佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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| 14. | (英) Node K (日) (読)
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| ○題名 (必須): | □ | (英) Effects of canagliflozin on NT-proBNP stratified by left ventricular diastolic function in patients with type 2 diabetes and chronic heart failure: a sub analysis of the CANDLE trial (日)
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| ○要約 (任意): | □ | (英) Identification of the effective subtypes of treatment for heart failure (HF) is an essential topic for optimizing treatment of the disorder. We hypothesized that the beneficial effect of SGLT2 inhibitors (SGLT2i) on the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) might depend on baseline diastolic function. To elucidate the effects of SGLT2i in type 2 diabetes mellitus (T2DM) and chronic HF we investigated, as a post-hoc sub-study of the CANDLE trial, the effects of canagliflozin on NT-proBNP levels from baseline to 24 weeks, with the data stratified by left ventricular (LV) diastolic function at baseline. Patients (n = 233) in the CANDLE trial were assigned randomly to either an add-on canagliflozin (n = 113) or glimepiride treatment groups (n = 120). The primary endpoint was a comparison between the two groups of the changes from baseline to 24 weeks in NT-pro BNP levels, stratified according to baseline ventricular diastolic function. The change in the geometric mean of NT-proBNP level from baseline to 24 weeks was 0.98 (95% CI 0.89-1.08) in the canagliflozin group and 1.07 (95% CI 0.97-1.18) in the glimepiride group. The ratio of change with canagliflozin/glimepiride was 0.93 (95% CI 0.82-1.05). Responder analyses were used to investigate the response of an improvement in NT-proBNP levels. Although the subgroup analyses for septal annular velocity (SEP-e') showed no marked heterogeneity in treatment effect, the subgroup with an SEP-e' < 4.7 cm/s indicated there was an association with lower NT-proBNP levels in the canagliflozin group compared with that in the glimepiride group (ratio of change with canagliflozin/glimepiride (0.83, 95% CI 0.66-1.04). In the subgroup with a lower LV diastolic function, canagliflozin showed a trend of reduced NT-pro BNP levels compared to that observed with glimepiride. This study suggests that the beneficial effects of canagliflozin treatment may be different in subgroups classified by the severity of LV diastolic dysfunction. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Cardiovascular Diabetology ([BioMed Central Ltd.])
(eISSN: 1475-2840)
| ○ISSN (任意): | □ | 1475-2840
ISSN: 1475-2840
(eISSN: 1475-2840) Title: Cardiovascular diabetologyTitle(ISO): Cardiovasc DiabetolPublisher: BioMed Central (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 20
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 186 186
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2021年 9月 14日 (令和 3年 9月 14日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1186/s12933-021-01380-w (→Scopusで検索)
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| ○PMID (任意): | □ | 34521417 (→Scopusで検索)
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| ○Scopus (任意): | □ | 2-s2.0-85115075981
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1186/s12933-021-01380-w (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Canagliflozin (日)
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| 4. | (英) KeywordList.Keyword: Diastolic function (日)
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| 5. | (英) KeywordList.Keyword: Echocardiography (日)
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| 6. | (英) KeywordList.Keyword: NT-proBNP (日)
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| 7. | (英) KeywordList.Keyword: Type 2 diabetes mellitus (日)
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