| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Ichihara Yuko (日) 市原 裕子 (読) いちはら ゆうこ
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 須賀 健一 ([徳島大学.病院.中央診療施設等.地域小児科診療部])
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| 3. | (英) Fukui Maika (日) 福井 真衣果 (読) ふくい まいか
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| ○学籍番号 (推奨): | □ | ****
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| 4. | 米谷 直人
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| 5. | (英) Shono Miki (日) 庄野 実希 (読) しょうの みき
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| ○学籍番号 (推奨): | □ | ****
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| 6. | 中川 竜二 ([徳島大学.病院.中央診療施設等.周産母子センター])
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| 7. | 香美 祥二 ([徳島大学])
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| ○題名 (必須): | □ | (英) Serum biotin level during pregnancy is associated with fetal growth and preterm delivery (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Background : Biotin is a water-soluble vitamin that plays various biological roles through histone modification, such as immune functions and fetal growth. Mammalian maternal biotin deficiency during gestation induces fetal growth restriction. Preterm infants are known to be marginal biotin deficiency. However, studies on the biotin status of pregnant women under various conditions are lacking. Method : This was a retrospective case control study to analyze serum biotin concentration during pregnancy and cord blood in normal pregnancy, preterm delivery and small-for-gestational-age (SGA). Results : Twenty pregnant women with normal term delivery, 35 with preterm delivery, 24 with SGA, and 10 non-pregnant adult women were enrolled. Serum biotin concentrations of pregnant women remained low from first to third trimester. The levels of serum biotin in cord blood showed a significant positive correlation with gestational age, and that of pregnant women showed a weak positive correlation with gestational age. The maternal serum biotin levels during second and third trimester of SGA group were significantly lower than those of normal term delivery. Conclusion : This study suggests that maternal biotin deficiency during pregnancy might be the risk of preterm labor or fetal growth restriction. Further studies are required to clarify the roles of biotin in perinatal medicine. J. Med. Invest. 67 : 170-173, February, 2020. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Biotin (日) (読)
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| 3. | (英) Female (日) (読)
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| 4. | (英) Fetal Blood (日) (読)
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| 5. | (英) Fetal Development (日) (読)
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| 6. | (英) Fetal Growth Retardation (日) (読)
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| 7. | (英) Humans (日) (読)
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| 8. | (英) Infant, Small for Gestational Age (日) (読)
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| 9. | (英) Pregnancy (日) (読)
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| 10. | (英) Premature Birth (日) (読)
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| 11. | (英) Retrospective Studies (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
(Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 67
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| ○号 (必須): | □ | 1.2
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| ○頁 (必須): | □ | 170 173
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2020年 0月 初日 (令和 2年 0月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.67.170 (→Scopusで検索)
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| ○PMID (任意): | □ | 32378602 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.2152/jmi.67.170 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: biotin (日)
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| 4. | (英) KeywordList.Keyword: fetal growth restriction (日)
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| 5. | (英) KeywordList.Keyword: pregnancy (日)
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| 6. | (英) KeywordList.Keyword: preterm birth (日)
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| 7. | (英) KeywordList.Keyword: small for gestational age (日)
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