| ○種別 (必須): | □ | 学術論文 (紀要その他)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 森根 裕二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 2. | 宇都宮 徹
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| 3. | 齋藤 裕 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 4. | 山田 眞一郎 ([徳島大学.病院.診療科.外科.消化器・移植外科])
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| 5. | 居村 暁
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| 6. | 池本 哲也 ([徳島大学.病院.中央診療施設等.安全管理部]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 7. | (英) Kitagawa Akihiro (日) (読)
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| 8. | (英) Kobayashi Yuta (日) (読)
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| 9. | (英) Takao Seiichiro (日) (読)
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| 10. | (英) Kosai Keisuke (日) (読)
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| 11. | (英) Mimori Koshi (日) (読)
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| 12. | (英) Tanaka Yasuhito (日) (読)
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| 13. | 島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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| ○題名 (必須): | □ | (英) Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma. (日)
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| ○要約 (任意): | □ | (英) Genome-wide analysis is widely applied to detect molecular alterations during oncogenesis and tumor progression. We analyzed DNA methylation profiles of hepatocellular carcinoma (HCC), and investigated the clinical role of most heypermethylated of tumor, encodes T-box 15 (TBX15), which was originally involved in mesodermal differentiation. We conducted a genome-wide analysis of DNA methylation of tumor and non-tumor tissue of 15 patients with HCC, and revealed was the most hypermethylated gene of tumor (Beta-value in tumor tissue = 0.52 compared with non-tumor tissue). Another validation set, which comprised 58 HCC with radical resection, was analyzed to investigate the relationships between tumor phenotype and mRNA expression. mRNA levels in tumor tissues were significantly lower compared with those of nontumor tissues ( < 0.0001). When we assigned a cutoff value = 0.5-fold, the overall survival 5-year survival rates of the low-expression group ( = 17) were significantly shorter compared with those of the high-expression group ( = 41) (43.3% vs. 86.2%, = 0.001). Multivariate analysis identified low expression as an independent prognostic factor for overall and disease-free survival. Therefore, genome-wide DNA methylation profiling indicates that hypermethylation and reduced expression of in tumor tissue represents a potential biomarker for predicting poor survival of patients with HCC. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Oncotarget (Impact Journals)
(eISSN: 1949-2553)
| ○ISSN (任意): | □ | 1949-2553
ISSN: 1949-2553
(eISSN: 1949-2553) Title: OncotargetTitle(ISO): OncotargetPublisher: Impact Journals (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 11
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| ○号 (必須): | □ | 52
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| ○頁 (必須): | □ | 4803 4812
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2020年 12月 29日 (令和 2年 12月 29日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.18632/oncotarget.27852 (→Scopusで検索)
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| ○PMID (任意): | □ | 33447348 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.18632/oncotarget.27852 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: genome-wide analysis (日)
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| 4. | (英) KeywordList.Keyword: hepatocellular carcinoma (日)
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| 5. | (英) KeywordList.Keyword: methylation (日)
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| 6. | (英) KeywordList.Keyword: prognostic biomarker (日)
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| 7. | (英) KeywordList.Keyword: tumor suppressor gene (日)
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| 8. | (英) CoiStatement: CONFLICTS OF INTEREST Authors have no conflicts of interest to declare. (日)
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