| ○種別 (必須): | □ | 学術論文 (紀要その他)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | 和田 佑馬 ([徳島大学.病院.診療科.外科.消化器・移植外科])
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| 2. | 森根 裕二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 3. | 居村 暁
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| 4. | 池本 哲也 ([徳島大学.病院.中央診療施設等.安全管理部]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 5. | 齋藤 裕 ([徳島大学.病院.診療科.外科.消化器・移植外科])
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| 6. | 髙須 千絵 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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| 7. | 山田 眞一郎 ([徳島大学.病院.診療科.外科.消化器・移植外科])
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| 8. | 島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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| ○題名 (必須): | □ | (英) HIF-1 expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis. (日)
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| ○要約 (任意): | □ | (英) The role of hypoxia-inducible factor-1 (HIF-1 ) in primary colorectal cancer (CRC) and colorectal liver metastasis (CRLM) has remained unclear. The aim of this study was to investigate HIF-1 expression and its association with prognosis in patients with CRLM with a focus on hepatic stellate cells (HSCs). Colon cancer cells were cultured in HSC-conditioned medium (CM), and HIF-1 expression and cell migration were analyzed. Seventy-five patients with CRLM who underwent an initial curative hepatectomy were enrolled. We examined HIF-1 expressions and patient prognosis between primary CRCs and the matched liver metastatic specimens. Activated HSCs induced HIF-1 mRNA and protein expression in colon cancer cells (p < 0.01) and promoted cell migration (p < 0.01). The positive rates of HIF-1 expression in primary CRCs and liver metastases were 68.0 and 72.0%, respectively. There were no differences in overall (OS) and disease-free survival (DFS) of HIF-1 expression in primary CRC. However, HIF-1 expression in liver metastasis correlated to poor prognosis in both OS and DFS. Furthermore, patients with HIF-1 positive expression in liver metastasis had poor prognosis. HIF-1 expression in liver metastasis determines poor prognosis of CRLM patients. HSCs might play a key role in aggressive phenotypes of tumor cells. (日)
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| ○キーワード (推奨): | 1. | (英) Colonic Neoplasms (日) (読)
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| 2. | (英) Colorectal Neoplasms (日) (読)
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| 3. | (英) Humans (日) (読)
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| 4. | (英) Hypoxia-Inducible Factor 1, alpha Subunit (日) (読)
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| 5. | (英) Liver Neoplasms (日) (読)
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| 6. | (英) Prognosis (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | World Journal of Surgical Oncology ([BioMed Central Ltd.])
(eISSN: 1477-7819)
| ○ISSN (任意): | □ | 1477-7819
ISSN: 1477-7819
(eISSN: 1477-7819) Title: World journal of surgical oncologyTitle(ISO): World J Surg OncolPublisher: BioMed Central (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 18
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 241 241
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2020年 9月 7日 (令和 2年 9月 7日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1186/s12957-020-02012-5 (→Scopusで検索)
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| ○PMID (任意): | □ | 32895059 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1186/s12957-020-02012-5 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Colorectal liver metastasis (日)
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| 4. | (英) KeywordList.Keyword: HIF-1 (日)
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| 5. | (英) KeywordList.Keyword: Molecular biology (日)
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| 6. | (英) KeywordList.Keyword: Prognostic factor (日)
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