| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
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| ○著者 (必須): | 1. | 坂根 亜由子 ([徳島大学.フォトニクス健康フロンティア研究院])
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| 2. | 矢野 隆章 ([徳島大学.ポストLEDフォトニクス研究所])
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| 3. | (英) Uchihashi Takayuki (日) (読)
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| 4. | 堀川 一樹 ([徳島大学.先端研究推進センター.バイオイメージング研究部門])
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| 5. | 原 佑介
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| 6. | (英) Imoto Issei (日) (読)
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| 7. | 栗栖 修作
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| 8. | (英) Yamada Hiroshi (日) (読)
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| 9. | (英) Takei Kohji (日) (読)
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| 10. | 佐々木 卓也 ([徳島大学.事務局.研究・産学連携部])
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| ○題名 (必須): | □ | (英) JRAB/MICAL-L2 undergoes liquid-liquid phase separation to form tubular recycling endosomes. (日)
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| ○要約 (任意): | □ | (英) Elongated tubular endosomes play essential roles in diverse cellular functions. Multiple molecules have been implicated in tubulation of recycling endosomes, but the mechanism of endosomal tubule biogenesis has remained unclear. In this study, we found that JRAB/MICAL-L2 induces endosomal tubulation via activated Rab8A. In association with Rab8A, JRAB/MICAL-L2 adopts its closed form, which functions in the tubulation of recycling endosomes. Moreover, JRAB/MICAL-L2 induces liquid-liquid phase separation, initiating the formation of tubular recycling endosomes upon overexpression. Between its N-terminal and C-terminal globular domains, JRAB/MICAL-L2 contains an intrinsically disordered region, which contributes to the formation of JRAB/MICAL-L2 condensates. Based on our findings, we propose that JRAB/MICAL-L2 plays two sequential roles in the biogenesis of tubular recycling endosomes: first, JRAB/MICAL-L2 organizes phase separation, and then the closed form of JRAB/MICAL-L2 formed by interaction with Rab8A promotes endosomal tubulation. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Communications Biology (Nature Publishing Group UK)
(eISSN: 2399-3642)
| ○ISSN (任意): | □ | 2399-3642
ISSN: 2399-3642
(eISSN: 2399-3642) Title: Communications biologyTitle(ISO): Commun BiolPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 4
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 551 551
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| ○年月日 (必須): | □ | 西暦 2021年 5月 11日 (令和 3年 5月 11日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/s42003-021-02080-7 (→Scopusで検索)
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| ○PMID (任意): | □ | 33976349 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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