『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=373040EID:373040, Map:0, LastModified:2021年1月25日(月) 20:24:50, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[小暮 健太朗], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.福田 達也
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2. (英) Yoshimi Shintaroh (日) 吉見 真太朗 (読) よしみ しんたろう
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学籍番号 (推奨): **** [ユーザ]
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3.小暮 健太朗 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
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題名 (必須): (英) Leukocyte-mimetic liposomes penetrate into tumor spheroids and suppress spheroid growth by encapsulated doxorubicin  (日)    [継承]
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要約 (任意): (英) As leukocytes can penetrate into deep regions of a tumor mass, leukocyte-mimetic liposomes (LM-Lipo) containing leukocyte membrane proteins are also expected to penetrate into tumors by exerting properties of those membrane proteins. The aim of the present study was to examine whether LM-Lipo, which were recently demonstrated to actively pass through inflamed endothelial layers, can penetrate into tumor spheroids, and to investigate the potential of LM-Lipo for use as an anticancer drug carrier. We prepared LM-Lipo via intermembrane protein transfer from human leukemia cells; transfer of leukocyte membrane proteins onto the liposomes was determined by Western blotting. LM-Lipo demonstrated a significantly high association with human lung cancer A549 cells compared with plain liposomes, which contributed to effective anti-proliferative action by encapsulated doxorubicin hydrochloride (DOX). Confocal microscopic images showed that LM-Lipo, but not plain liposomes, could efficiently penetrate into A549 tumor spheroids. Moreover, DOX-encapsulated LM-Lipo significantly suppressed tumor spheroid growth. Thus, leukocyte membrane proteins transferred onto LM-Lipo retained their unique function, which allowed for efficient penetration of the liposomes into tumor spheroids, similar to leukocytes. In conclusion, these results suggest that LM-Lipo could be a useful tumor-penetrating drug delivery system for cancer treatment.  (日)    [継承]
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発行所 (推奨):
誌名 (必須): Journal of Pharmaceutical Sciences (American Pharmaceutical Association/American Pharmacists Association/Fédération internationale pharmaceutique/American Association of Pharmaceutical Scientists)
(pISSN: 0022-3549, eISSN: 1520-6017)

ISSN (任意): 1520-6017
ISSN: 0022-3549 (pISSN: 0022-3549, eISSN: 1520-6017)
Title: Journal of pharmaceutical sciences
Title(ISO): J Pharm Sci
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2020年 12月 初日 (令和 2年 12月 初日) [継承]
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DOI (任意): 10.1016/j.xphs.2020.10.049    (→Scopusで検索) [継承]
PMID (任意): 33129835    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85096382956 [継承]
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備考 (任意): 1.(英) Article.ELocationID: S0022-3549(20)30665-1  (日)    [継承]
2.(英) Article.ELocationID: 10.1016/j.xphs.2020.10.049  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) KeywordList.Keyword: Cancer  (日)    [継承]
5.(英) KeywordList.Keyword: Intermembrane protein transfer  (日)    [継承]
6.(英) KeywordList.Keyword: Leukocyte  (日)    [継承]
7.(英) KeywordList.Keyword: Leukocyte-mimetic drug delivery system  (日)    [継承]
8.(英) KeywordList.Keyword: Liposome  (日)    [継承]
9.(英) KeywordList.Keyword: Tumor spheroid  (日)    [継承]

標準的な表示

和文冊子 ● Tatsuya Fukuta, Shintaroh Yoshimi and Kentaro Kogure : Leukocyte-mimetic liposomes penetrate into tumor spheroids and suppress spheroid growth by encapsulated doxorubicin, Journal of Pharmaceutical Sciences, 2020.
欧文冊子 ● Tatsuya Fukuta, Shintaroh Yoshimi and Kentaro Kogure : Leukocyte-mimetic liposomes penetrate into tumor spheroids and suppress spheroid growth by encapsulated doxorubicin, Journal of Pharmaceutical Sciences, 2020.

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